| + |
UBE3A | down-regulates quantity by destabilization 
ubiquitination
|
ALDH1A2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265135 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 29076503 |
Hyperactivity of E3 ubiquitin (Ub) ligase UBE3A, stemming from 15q11-q13 copy number variations, accounts for 1%-3% of ASD cases worldwide, but the underlying mechanisms remain incompletely characterized. Here we report that the functionality of ALDH1A2, the rate-limiting enzyme of retinoic acid (RA) synthesis, is negatively regulated by UBE3A in a ubiquitylation-dependent manner. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ALDH1A2 | down-regulates quantity
chemical modification
|
retinal |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265125 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21621639 |
All-trans-retinoic acid (atRA) provides essential support to diverse biological systems and physiological processes.| An accrual of biochemical, physiological and genetic data have identified specific functional outcomes for the retinol dehydrogenases, RDH1, RDH10, and DHRS9, as physiological catalysts of the first step in atRA biosynthesis, and for the retinal dehydrogenases RALDH1, RALDH2, and RALDH3, as catalysts of the second and irreversible step. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Retinoic Acid Metabolism |
| + |
ALDH1A2 | up-regulates quantity 
chemical modification
|
all-trans-retinoic acid |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265126 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21621639 |
All-trans-retinoic acid (atRA) provides essential support to diverse biological systems and physiological processes.| An accrual of biochemical, physiological and genetic data have identified specific functional outcomes for the retinol dehydrogenases, RDH1, RDH10, and DHRS9, as physiological catalysts of the first step in atRA biosynthesis, and for the retinal dehydrogenases RALDH1, RALDH2, and RALDH3, as catalysts of the second and irreversible step. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Retinoic Acid Metabolism |
3.0
ALDH1A2
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