Summary

Name ATG12
Full Name Ubiquitin-like protein ATG12
Synonyms Autophagy-related protein 12, APG12-like | APG12, APG12L
Primary ID O94817
Links - -
Type protein
Relations 4
Pathways Autophagy
Function Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes.

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Relations

Regulator Mechanism target score ℹ
+ ATG10up-regulates img/direct-activation.png binding ATG12 0.874
Publications: 1 Organism: Homo Sapiens
Pathways:Autophagy
+ ATG12up-regulates img/indirect-activation.png Autophagosome_formation 0.7
Publications: 1 Organism: Saccharomyces Cerevisiae
Pathways:Autophagy
+ ATG7up-regulates img/direct-activation.png binding ATG12 0.935
Publications: 1 Organism: Homo Sapiens
Pathways:Autophagy
+ ATG12form complex img/form-complex.png binding ATG12/5/16L1 0.864
Publications: 1 Organism: Homo Sapiens
Tissue: HEK-293 Cell
Pathways:Autophagy