Summary

Name ATG7
Full Name Ubiquitin-like modifier-activating enzyme ATG7
Synonyms ATG12-activating enzyme E1 ATG7, Autophagy-related protein 7, APG7-like, hAGP7, Ubiquitin-activating enzyme E1-like protein | APG7L
Primary ID O95352
Links - -
Type protein
Relations 5
Pathways Autophagy
Function E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation. Plays a role in regulating the liver clock and glucose metabolism by mediating the autophagic degradation of CRY1 (clock repressor) in a time-dependent manner (By similarity).

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Relations

Regulator Mechanism target score ℹ
+ ATG7up-regulates activity img/direct-activation.png binding GABARAPL2 0.903
Publications: 1 Organism: In Vitro
Pathways:Autophagy
+ ATG7up-regulates img/direct-activation.png binding ATG12 0.935
Publications: 1 Organism: Homo Sapiens
Pathways:Autophagy
+ ATG7up-regulates img/direct-activation.png binding MAP1LC3B 0.869
Publications: 1 Organism: Homo Sapiens
+ ATG7up-regulates img/direct-activation.png binding MAP1LC3A 0.867
Publications: 1 Organism: Homo Sapiens
+ ATG7up-regulates activity img/direct-activation.png binding MAP1LC3C 0.781
Publications: 1 Organism: Mus Musculus
Pathways:Autophagy