| + |
ATG12 | up-regulates 
|
Autophagosome_formation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-219396 |
|
|
Saccharomyces cerevisiae |
|
| pmid |
sentence |
| 23321721 |
Dissecting the role of the Atg12-Atg5-Atg16 complex during autophagosome formation |
|
| Publications: |
1 |
Organism: |
Saccharomyces Cerevisiae |
| Pathways: | Autophagy |
| + |
BECN1 | up-regulates
|
Autophagosome_formation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-219545 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20921139 |
Autophagy initiation signaling requires both the ULK1 kinase and the BECLIN 1VPS34 core complex to generate autophagosomes, double-membraned vesicles that transfer cellular contents to lysosomes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Fibroma Cell |
| Pathways: | Autophagy |
| + |
ATG12/5/16L1 | up-regulates
|
Autophagosome_formation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-226702 |
|
|
in vitro |
|
| pmid |
sentence |
| 23321721 |
Dissecting the role of the Atg12-Atg5-Atg16 complex during autophagosome formation |
|
| Publications: |
1 |
Organism: |
In Vitro |
| Pathways: | Autophagy |
| + |
ATG2A | up-regulates
|
Autophagosome_formation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268485 |
|
|
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 28561066 |
WIPI4 interacts with ATG2, AMPK and ULK1. Upon starvation and AMPK activation, WIPI4-ATG2 dissociates from AMPK and ULK1 and localizes at nascent autophagosomes, potentially supporting further autophagosome maturation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP1LC3B | up-regulates
|
Autophagosome_formation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-219403 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20921139 |
We assessed both conversion of LC3-I to its cleaved and lipidated form LC3-II and its translocation to autophagic structures, two steps in autophagosome formation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP1LC3A | up-regulates
|
Autophagosome_formation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-219406 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20921139 |
We assessed both conversion of LC3-I to its cleaved and lipidated form LC3-II and its translocation to autophagic structures, two steps in autophagosome formation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Fibroma Cell |
| + |
ATG2B | up-regulates
|
Autophagosome_formation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268486 |
|
|
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 28561066 |
WIPI4 interacts with ATG2, AMPK and ULK1. Upon starvation and AMPK activation, WIPI4-ATG2 dissociates from AMPK and ULK1 and localizes at nascent autophagosomes, potentially supporting further autophagosome maturation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAP1LC3C | up-regulates
|
Autophagosome_formation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-219399 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20921139 |
We assessed both conversion of LC3-I to its cleaved and lipidated form LC3-II and its translocation to autophagic structures, two steps in autophagosome formation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Fibroma Cell |
| Pathways: | Autophagy |
| + |
Vps34 Complex I | up-regulates
|
Autophagosome_formation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260323 |
|
|
|
|
| pmid |
sentence |
| 30397185 |
PtdIns3P recruits specific recognition modules that are common in protein-sorting pathways, such as autophagy and endocytic sorting. It is best characterized in two heterotetramers, complexes I and II. Complex I is composed of VPS34, VPS15, Beclin 1, and autophagy-related gene (ATG)14L, whereas complex II replaces ATG14L with UVRAG. |Complexes I and II are critical for early events in autophagy and endocytic sorting, respectively. |
|
| Publications: |
1 |
| Pathways: | Autophagy |
| + |
Vps34 Complex II | up-regulates
|
Autophagosome_formation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260324 |
|
|
|
|
| pmid |
sentence |
| 30397185 |
PtdIns3P recruits specific recognition modules that are common in protein-sorting pathways, such as autophagy and endocytic sorting. It is best characterized in two heterotetramers, complexes I and II. Complex I is composed of VPS34, VPS15, Beclin 1, and autophagy-related gene (ATG)14L, whereas complex II replaces ATG14L with UVRAG. |Complexes I and II are critical for early events in autophagy and endocytic sorting, respectively. |
|
| Publications: |
1 |
| Pathways: | Autophagy |
3.0
Autophagosome_formation