+ |
Cullin 3-RBX1-Skp1 | up-regulates activity
monoubiquitination
|
SEC31A |
0.386 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-272012 |
|
lys647 |
Homo sapiens |
HeLa Cell |
pmid |
sentence |
22358839 |
By analyzing mouse embryonic stem cell (mESC) division, we have identified Cul3Klhl12 as a regulator of COPII coat formation. Cul3Klhl12 monoubiquitinates Sec31 and drives assembly of large COPII-coats. As a result, ubiquitination by Cul3Klhl12 is essential for collagen export, a step that is required for integrin-dependent mESC division. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-272013 |
|
lys1217 |
Homo sapiens |
HeLa Cell |
pmid |
sentence |
22358839 |
By analyzing mouse embryonic stem cell (mESC) division, we have identified Cul3Klhl12 as a regulator of COPII coat formation. Cul3Klhl12 monoubiquitinates Sec31 and drives assembly of large COPII-coats. As a result, ubiquitination by Cul3Klhl12 is essential for collagen export, a step that is required for integrin-dependent mESC division. |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
+ |
KLHL12 | up-regulates activity
binding
|
SEC31A |
0.591 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-272010 |
|
|
Homo sapiens |
HeLa Cell |
pmid |
sentence |
22358839 |
By analyzing mouse embryonic stem cell (mESC) division, we have identified Cul3Klhl12 as a regulator of COPII coat formation. Cul3Klhl12 monoubiquitinates Sec31 and drives assembly of large COPII-coats. As a result, ubiquitination by Cul3Klhl12 is essential for collagen export, a step that is required for integrin-dependent mESC division. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
SEC31A | form complex
binding
|
COPII vesicle |
0.755 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-265292 |
|
|
Homo sapiens |
HeLa Cell |
pmid |
sentence |
30605680 |
The Core Components of COPII Vesicles from HeLa Cells|Membrane-bound Sar1 then recruits the inner COPII coat subcomplex, the Sec23/24 heterodimer. Subsequently, together with cargo proteins recruited by the Sec24 subunit, Sar1 and Sec23/24 assemble into so-called pre-budding complexes. Finally, outer coat subcomplexes, comprising heterotetrameric Sec13/31 complexes, are recruited onto pre-budding complexes to complete the two-layered COPII coat |
|
Publications: |
1 |
Organism: |
Homo Sapiens |