3.0
Summary
| Name |  KAT7View Modifications |
| Full Name | Histone acetyltransferase KAT7 |
| Synonyms | Histone acetyltransferase binding to ORC1, Lysine acetyltransferase 7, MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2, MYST-2 | HBO1, HBOa, MYST2 |
| Primary ID | O95251 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Function | Catalytic subunit of histone acetyltransferase HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby regulating various processes, such as gene transcription, protein ubiquitination, immune regulation, stem cell pluripotent and self-renewal maintenance and embryonic development (PubMed:16387653, PubMed:21753189, PubMed:24065767, PubMed:26620551, PubMed:31767635, PubMed:31827282). Some complexes also catalyze acetylation of histone H4 at 'Lys-5', 'Lys-8' and 'Lys-12' (H4K5ac, H4K8ac and H4K12ac, respectively), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:10438470, PubMed:19187766, PubMed:20129055, PubMed:24065767). Specificity of the HBO1 complexes is determined by the scaffold subunit |
Viewer
Search Tools
Refine search:
- by mechanism
- by effect
- by organism:
- by tissue:
- by cell-line
Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PLK1 | up-regulates 
phosphorylation
|
KAT7 | 0.516 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PRKD1 | up-regulates quantity by stabilization
phosphorylation
|
KAT7 | 0.2 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | CDK1 | up-regulates
phosphorylation
|
KAT7 | 0.361 |
| Publications: | 2 | Organism: | Homo Sapiens | |