Summary

Name HUWE1
Full Name E3 ubiquitin-protein ligase HUWE1
Synonyms ARF-binding protein 1, ARF-BP1, HECT, UBA and WWE domain-containing protein 1, HECT-type E3 ubiquitin transferase HUWE1, Homologous to E6AP carboxyl terminus homologous protein 9, HectH9, Large structure of UREB1, LASU1, Mcl-1 ubiquitin ligase E3, Mule, Upstream regulatory element-binding protein 1, URE-B1, URE-binding protein 1 | KIAA0312, KIAA1578, UREB1
Primary ID Q7Z6Z7
Links - -
Type protein
Relations 7
Function E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15989957, PubMed:19713937, PubMed:15567145, PubMed:15767685, PubMed:18488021, PubMed:17567951, PubMed:19037095, PubMed:20534529). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529).

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ HUWE1down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination POLL 0.313
Publications: 3 Organism: Homo Sapiens
+ Ub:E2up-regulates activity img/direct-activation.png ubiquitination HUWE1 0.2
Publications: 1 Organism: Homo Sapiens
+ AMBRA1up-regulates activity img/direct-activation.png relocalization HUWE1 0.2
Publications: 1 Organism: Homo Sapiens
+ HUWE1down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination MFN2 0.43
Publications: 1 Organism: Homo Sapiens
+ HUWE1down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination MCL1 0.517
Publications: 1 Organism: Homo Sapiens