3.0
Summary
| Name |  HUWE1View Modifications |
| Full Name | E3 ubiquitin-protein ligase HUWE1 |
| Synonyms | ARF-binding protein 1, ARF-BP1, HECT, UBA and WWE domain-containing protein 1, HECT-type E3 ubiquitin transferase HUWE1, Homologous to E6AP carboxyl terminus homologous protein 9, HectH9, Large structure of UREB1, LASU1, Mcl-1 ubiquitin ligase E3, Mule, Upstream regulatory element-binding protein 1, URE-B1, URE-binding protein 1 | KIAA0312, KIAA1578, UREB1 |
| Primary ID | Q7Z6Z7 |
| Links |  -  -  |
| Type | protein |
| Relations | 20 |
| Function | E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15989957, PubMed:19713937, PubMed:15567145, PubMed:15767685, PubMed:18488021, PubMed:17567951, PubMed:19037095, PubMed:20534529). Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1 (PubMed:15989957). Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair (PubMed:19713937). Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4 (PubMed:15567145, PubMed:15767685, PubMed:15989956). Ubiquitinates MFN2 to negatively regulate mitochondrial fusion in response to decreased stearoylation of TFRC (PubMed:26214738). Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN (PubMed:18488021). May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation (PubMed:17567951). Mediates polyubiquitination of isoform 2 of PA2G4 (PubMed:19037095). Acts in concert with MYCBP2 to regulate the circadian clock gene expression by promoting the lithium-induced ubiquination and degradation of NR1D1 (PubMed:20534529). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | HUWE1 | down-regulates quantity by destabilization 
polyubiquitination
|
POLL | 0.312 |
| Publications: | 3 | Organism: | Homo Sapiens | |
| + | Ub:E2 | up-regulates activity 
ubiquitination
|
HUWE1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | HUWE1 | down-regulates quantity by destabilization
ubiquitination
|
TP53 | |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | HUWE1 | down-regulates quantity by destabilization
ubiquitination
|
CHEK1 | |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | HUWE1 | down-regulates quantity by destabilization
ubiquitination
|
BRCA1 | |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | HUWE1 | down-regulates quantity by destabilization
ubiquitination
|
KAT7 | |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | HUWE1 | down-regulates quantity
ubiquitination
|
ATOH1 | |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | HUWE1 | down-regulates quantity
ubiquitination
|
MYOD1 | |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | HUWE1 | down-regulates quantity by destabilization
ubiquitination
|
NEIL1 | |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | HUWE1 | down-regulates quantity
ubiquitination
|
TBP | |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | HUWE1 | down-regulates quantity by destabilization
ubiquitination
|
ZBTB17 | |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | HUWE1 | down-regulates quantity by destabilization
ubiquitination
|
KLF4 | |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | HUWE1 | down-regulates quantity by destabilization
ubiquitination
|
MYCN | |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | HUWE1 | down-regulates quantity
ubiquitination
|
PTOV1 | |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | HUWE1 | down-regulates quantity by destabilization
ubiquitination
|
PPARA | |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | HUWE1 | down-regulates quantity by destabilization
ubiquitination
|
MFN2 | 0.428 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | AMBRA1 | up-regulates activity
relocalization
|
HUWE1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | HUWE1 | down-regulates quantity by destabilization
ubiquitination
|
MCL1 | 0.514 |
| Publications: | 1 | Organism: | Homo Sapiens | |