3.0
Summary
| Name |  SNAPINView Modifications |
| Full Name | SNARE-associated protein Snapin |
| Synonyms | Biogenesis of lysosome-related organelles complex 1 subunit 7, BLOC-1 subunit 7, Synaptosomal-associated protein 25-binding protein, SNAP-associated protein | BLOC1S7, SNAP25BP, SNAPAP |
| Primary ID | O95295 |
| Links |  -  -  |
| Type | protein |
| Relations | 6 |
| Function | Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells (PubMed:17182842, PubMed:18167355). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKACA | up-regulates activity 
phosphorylation
|
SNAPIN | 0.311 |
| Publications: | 1 | |||
| + | LRRK2 | down-regulates 
phosphorylation
|
SNAPIN | 0.53 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Brain | |||
| + | RNF13 | up-regulates activity
polyubiquitination
|
SNAPIN | 0.537 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| + | SNAPIN | form complex 
binding
|
BLOC-1 | 0.713 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TOR1A | up-regulates activity
binding
|
SNAPIN | 0.434 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SNAPIN | up-regulates activity
binding
|
SNAP25 | 0.601 |
| Publications: | 1 | Organism: | Homo Sapiens | |