Summary

Name SNAPIN
Full Name SNARE-associated protein Snapin
Synonyms Biogenesis of lysosome-related organelles complex 1 subunit 7, BLOC-1 subunit 7, Synaptosomal-associated protein 25-binding protein, SNAP-associated protein | BLOC1S7, SNAP25BP, SNAPAP
Primary ID O95295
Links - -
Type protein
Relations 2
Function Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells (PubMed:17182842, PubMed:18167355). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation SNAPIN 0.14
Publications: 1
+ down-regulates img/direct_inhibition.png phosphorylation SNAPIN 0.22
Publications: 1 Organism: Homo Sapiens
Tissue: Brain