3.0
Summary
| Name |  TNFAIP8
|
| Full Name | Tumor necrosis factor alpha-induced protein 8 |
| Synonyms | TNF alpha-induced protein 8, Head and neck tumor and metastasis-related protein, MDC-3.13, NF-kappa-B-inducible DED-containing protein, NDED, SCC-S2, TNF-induced protein GG2-1 | |
| Primary ID | O95379 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation. |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | GNAI1 | up-regulates activity 
binding
|
TNFAIP8 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | GNAI2 | up-regulates activity
binding
|
TNFAIP8 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | GNAI3 | up-regulates activity
binding
|
TNFAIP8 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |