Relation Results

Summary

Name GDF11
Full Name Growth/differentiation factor 11
Synonyms GDF-11, Bone morphogenetic protein 11, BMP-11 | BMP11
Primary ID O95390
Links - -
Type protein
Relations 4
Function Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. May play critical roles in pat ...
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Type: Score: Layout: SPV 
0.6320.20.67GDF11ACVR2BACTR2FST

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Relations
Regulator
Mechanism
target
score ℹ
+ GDF11up-regulates img/direct-activation.png binding ACVR2B 0.632
Identifier Residue Sequence Organism Cell Line
SIGNOR-95309 Homo sapiens
pmid sentence
Here we demonstrate using genetic and biochemical studies that actriib and its subfamily receptor, actriia, cooperatively mediate the gdf11 signal in patterning the axial vertebrae, and that gdf11 binds to both actriia and actriib, and induces phosphorylation of smad2
Identifier Residue Sequence Organism Cell Line
SIGNOR-147940 Homo sapiens
pmid sentence
The identity of the receptors that mediate gdf11 signalling during embryogenesis remains unclear. gdf11 could only bind directly to acvr2b but not to any type i receptor
Publications: 2 Organism: Homo Sapiens
Tissue: Kidney
+ GDF11up-regulates img/direct-activation.png binding ACTR2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-144147 Homo sapiens
pmid sentence
Here we demonstrate using genetic and biochemical studies that actriib and its subfamily receptor, actriia, cooperatively mediate the gdf11 signal in patterning the axial vertebrae, and that gdf11 binds to both actriia and actriib, and induces phosphorylation of smad2.
Publications: 1 Organism: Homo Sapiens
+ FSTdown-regulates activity img/direct_inhibition.png binding GDF11 0.67
Identifier Residue Sequence Organism Cell Line
SIGNOR-251716 Mus musculus
pmid sentence
Follistatin (FST) is a member of the tissue growth factor β family and is a secreted glycoprotein that antagonizes many members of the family, including activin A, growth differentiation factor 11, and myostatin. |FST315-ΔHBS-Fc induced improvements in muscle repair after injury/atrophy by modulating the early inflammatory phase allowing for increased macrophage density, and Pax7-positive cells leading to an accelerated restoration of myofibers and muscle function.
Publications: 1 Organism: Mus Musculus
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