| + |
GDNF | up-regulates quantity by expression 
transcriptional regulation
|
FST |
0.266 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252188 |
|
|
Rattus norvegicus |
Neural Stem Cell |
| pmid |
sentence |
| 15212950 |
We characterize the network of 43 genes induced by GDNF overproduction of neuronal progenitor cells (ST14A), which mainly regulate migration and differentiation of neuronal progenitor cells.Laminin, Mpl3, Alcam, Bin1, Id1, Id2, Id3, neuregulin1, the ephrinB2-receptor, neuritin, focal adhesion kinase (FAK), Tc10, Pdpk1, clusterin, GTP-cyclooxygenase1, and follistatin are genes up-regulated by GDNF overexpression. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
NFATC2 | up-regulates quantity by expression 
transcriptional regulation
|
FST |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251729 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 15130492 |
MyoD, CREB, and NFAT Mediate the Transcriptional Activation of the Follistatin Promoter Induced by TSA |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FST | down-regulates activity 
binding
|
GDF11 |
0.663 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251716 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 24627466 |
Follistatin (FST) is a member of the tissue growth factor β family and is a secreted glycoprotein that antagonizes many members of the family, including activin A, growth differentiation factor 11, and myostatin. |FST315-ΔHBS-Fc induced improvements in muscle repair after injury/atrophy by modulating the early inflammatory phase allowing for increased macrophage density, and Pax7-positive cells leading to an accelerated restoration of myofibers and muscle function. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MYOD1 | up-regulates quantity by expression
transcriptional regulation
|
FST |
0.388 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251727 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 15130492 |
MyoD, CREB, and NFAT Mediate the Transcriptional Activation of the Follistatin Promoter Induced by TSA |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
FST | down-regulates activity
binding
|
MSTN |
0.726 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235150 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 11459935 |
Binding of myostatin to Act RIIB could be inhibited by the activin-binding protein follistatin and, at higher concentrations, by the myostatin propeptide. T |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251717 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 24627466 |
Follistatin (FST) is a member of the tissue growth factor beta family and is a secreted glycoprotein that antagonizes many members of the family, including activin A, growth differentiation factor 11, and myostatin. FST315-deltaHBS-Fc induced improvements in muscle repair after injury/atrophy by modulating the early inflammatory phase allowing for increased macrophage density, and Pax7-positive cells leading to an accelerated restoration of myofibers and muscle function. |
|
| Publications: |
2 |
Organism: |
Mus Musculus |
| + |
FST | down-regulates activity
binding
|
INHBA |
0.846 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235134 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22037168 |
Blocking activin action by pre-treatment with its binding protein, follistatin, modifies the inflammatory cytokine cascade, and reduces the severity of the subsequent inflammatory response and mortality |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251715 |
|
|
Mus musculus |
Skeletal Muscle Satellite Cell |
| pmid |
sentence |
| 24627466 |
Follistatin (FST) is a member of the tissue growth factor β family and is a secreted glycoprotein that antagonizes many members of the family, including activin A, growth differentiation factor 11, and myostatin. |FST315-ΔHBS-Fc induced improvements in muscle repair after injury/atrophy by modulating the early inflammatory phase allowing for increased macrophage density, and Pax7-positive cells leading to an accelerated restoration of myofibers and muscle function. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, Mus Musculus |
| + |
CREB1 | up-regulates quantity by expression
transcriptional regulation
|
FST |
0.251 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251714 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 15130492 |
MyoD, CREB, and NFAT Mediate the Transcriptional Activation of the Follistatin Promoter Induced by TSA |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
LEF1 | up-regulates quantity by expression
transcriptional regulation
|
FST |
0.28 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251722 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 24344199 |
We further demonstrate that Fst is a direct target of the WNT/β-catenin pathway. Activation and inactivation of β-catenin induced and inhibited Fst expression, respectively, in both C2C12 cells and mouse embryos. Specific TCF/LEF1 binding sites within the promoter and intron 1 region of the Fst gene were required for RSPO2 and WNT/β-catenin-induced Fst expression. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
4.0
FST
- 
- 