4.0
Summary
| Name |  AHSA1View Modifications |
| Full Name | Activator of 90 kDa heat shock protein ATPase homolog 1 |
| Synonyms | AHA1, p38 | C14orf3 |
| Primary ID | O95433 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Acts as a co-chaperone of HSP90AA1 (PubMed:29127155). Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity (PubMed:29127155). Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:29127155). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | ABL1 | up-regulates activity 
phosphorylation
|
AHSA1 | 0.252 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | AHSA1 | up-regulates activity
binding
|
HSP90AA1 | 0.74 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | AHSA1 | up-regulates activity
binding
|
GCH1 | 0.295 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | AHSA1 | up-regulates activity
binding
|
HSP90AB1 | 0.659 |
| Publications: | 1 | Organism: | Homo Sapiens | |