+ |
PCM1 | up-regulates
relocalization
|
PCNT |
0.675 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-95117 |
|
|
Homo sapiens |
|
pmid |
sentence |
12403812 |
Rna silencing of pcm-1 leads to reduced assembly of centrin, pericentrin, and ninein at the centrosome |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
PCNT | up-regulates activity
binding
|
CDK5RAP2 |
0.812 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-260309 |
|
|
Homo sapiens |
U2-OS Cell |
pmid |
sentence |
18042621 |
Our observation that Cep215 may function downstream of pericentrin suggests that the two proteins affect centrosome cohesion through a common mechanism. |Finally, depletion of pericentrin caused an almost complete loss of Cep215 from centrosomes, a detectable reduction in centrosomal levels of Cep68 and rootletin, but no significant effect on C-Nap1 (Fig. 6C and Table 1). Taken together, these results point to functional (and perhaps molecular) interactions between (1) Cep68 and rootletin and (2) Cep215 and pericentrin. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
CEP68 | up-regulates activity
relocalization
|
PCNT |
0.346 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-275623 |
|
|
|
|
pmid |
sentence |
25503564 |
We also found that Cep68 forms a complex with Cep215 (also known as Cdk5Rap2) and PCNT (also known as pericentrin), two PCM (pericentriolar material) proteins involved in centriole engagement. |Cep68 stabilization increases the amount of PCNT at metaphase centrosomes, but does not affect its removal at the end of mitosis |
|
Publications: |
1 |