Summary

Name FSTL3
Full Name Follistatin-related protein 3
Synonyms Follistatin-like protein 3, Follistatin-related gene protein | FLRG
Primary ID O95633
Links - -
Type protein
Relations 2
Function Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10.

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Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png binding MSTN 0.31
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FSTL3 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle