| + |
STK38 | down-regulates activity 
phosphorylation
|
YAP1 |
0.391 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259856 |
Ser109 |
KSHSRQAsTDAGTAG |
Homo sapiens |
|
| pmid |
sentence |
| 25601544 |
We performed mass spectrometry to determine additional sites on YAP1 targeted by NDR, identifying three additional serines, namely S61, S109, and S164, to also be phosphorylated by NDR in vitro |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259855 |
Ser127 |
PQHVRAHsSPASLQL |
Homo sapiens |
|
| pmid |
sentence |
| 25601544 |
We show that mammalian NDR1/2 kinases phosphorylate YAP1 on S127 and thereby negatively regulate YAP1 activity in tissue-cultured cells. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
OGT | up-regulates activity 
glycosylation
|
YAP1 |
0.286 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276942 |
Ser109 |
KSHSRQAsTDAGTAG |
|
|
| pmid |
sentence |
| 34155345 |
Mass spectrometry analysis showed that YAP was the effector protein modified by OGT. In details, YAP Ser109 O-GlcNAcylation promoted the malignant phenotypes in PTC cells by inducing YAP Ser127 dephosphorylation and activation. |
|
| Publications: |
1 |
| + |
PRKCZ | down-regulates quantity by destabilization
phosphorylation
|
YAP1 |
0.28 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276876 |
Ser109 |
KSHSRQAsTDAGTAG |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 25660024 |
Yap and β-catenin are direct substrates of PKCζ.We show here that PKCζ suppresses intestinal stem cell function by promoting the downregulation of β-catenin and Yap through direct phosphorylation.Consistent with MS/MS analysis, mutation to alanine of these two sites completely abolished Yap phosphorylation by PKCζ. Interestingly, S109 and T110 sites were highly conserved among species (Figure S3B), which suggested an important role in Yap regulation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276877 |
Thr110 |
SHSRQAStDAGTAGA |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 25660024 |
Yap and β-catenin are direct substrates of PKCζ.We show here that PKCζ suppresses intestinal stem cell function by promoting the downregulation of β-catenin and Yap through direct phosphorylation.Consistent with MS/MS analysis, mutation to alanine of these two sites completely abolished Yap phosphorylation by PKCζ. Interestingly, S109 and T110 sites were highly conserved among species (Figure S3B), which suggested an important role in Yap regulation. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
LATS1 | down-regulates
phosphorylation
|
YAP1 |
0.834 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-197647 |
Ser127 |
PQHVRAHsSPASLQL |
Homo sapiens |
|
| pmid |
sentence |
| 22658639 |
In response to high cell densities, activated LATS1/2 phosphorylates the WW-domain containing transcriptional co-activators YAP at Ser127 and TAZ at Ser89, promoting 14-3-3 binding and thereby inhibiting their translocation into the nucleus. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
LATS1/2 | down-regulates activity
phosphorylation
|
YAP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256188 |
Ser127 |
PQHVRAHsSPASLQL |
Homo sapiens |
|
| pmid |
sentence |
| 22658639 |
In response to high cell densities, activated LATS1/2 phosphorylates the WW-domain containing transcriptional co-activators YAP at Ser127 and TAZ at Ser89, promoting 14-3-3 binding and thereby inhibiting their translocation into the nucleus. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo in cancer, Hippo Signaling, Integrin Signaling |
| + |
AKT | down-regulates
phosphorylation
|
YAP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-97485 |
Ser127 |
PQHVRAHsSPASLQL |
Homo sapiens |
|
| pmid |
sentence |
| 12535517 |
One protein that associates with 14-3-3 in an akt-dependent manner is shown here to be the yes-associated protein (yap), which is phosphorylated by akt at serine 127, leading to binding to 14-3-3. Akt promotes yap localization to the cytoplasm, resulting in loss from the nucleus where it functions as a coactivator of transcription factors including p73. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Integrin Signaling |
| + |
PPM1A | up-regulates activity
dephosphorylation
|
YAP1 |
0.272 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276984 |
Ser127 |
PQHVRAHsSPASLQL |
Homo sapiens |
|
| pmid |
sentence |
| 33630828 |
Although the authors show an in vitro kinase assay where PPM1A supposedly dephosphorylates YAP on Ser127, Fig. 4A lacks a positive control to ensure that PPM1A purified from cells is active.|The protein phosphatase PPM1A dephosphorylates and activates YAP to govern mammalian intestinal and liver regeneration. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LATS2 | down-regulates
phosphorylation
|
YAP1 |
0.814 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198514 |
Ser127 |
PQHVRAHsSPASLQL |
Homo sapiens |
|
| pmid |
sentence |
| 22863277 |
Lats1/2 inhibit yap by direct phosphorylation at s127, which results in yap binding to 14-3-3 and cytoplasmic sequestration |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-197655 |
Ser127 |
PQHVRAHsSPASLQL |
Homo sapiens |
|
| pmid |
sentence |
| 22658639 |
In response to high cell densities, activated LATS1/2 phosphorylates the WW-domain containing transcriptional co-activators YAP at Ser127 and TAZ at Ser89, promoting 14-3-3 binding and thereby inhibiting their translocation into the nucleus. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
PPP1CA | up-regulates activity
dephosphorylation
|
YAP1 |
0.658 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276999 |
Ser127 |
PQHVRAHsSPASLQL |
Homo sapiens |
|
| pmid |
sentence |
| 21909427 |
In the present study, we demonstrate that PP1A (catalytic subunit of protein phosphatase-1) interacts with and dephosphorylates YAP2 in vitro and in vivo, and PP1A-mediated dephosphorylation induces the nuclear accumulation and transcriptional activation of YAP2.|PP1A dephosphorylates endogenous YAP2 at serine 127. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AKT1 | down-regulates
phosphorylation
|
YAP1 |
0.61 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252593 |
Ser127 |
PQHVRAHsSPASLQL |
Homo sapiens |
|
| pmid |
sentence |
| 12535517 |
One protein that associates with 14-3-3 in an akt-dependent manner is shown here to be the yes-associated protein (yap), which is phosphorylated by akt at serine 127, leading to binding to 14-3-3. Akt promotes yap localization to the cytoplasm, resulting in loss from the nucleus where it functions as a coactivator of transcription factors including p73. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK8 | up-regulates activity
phosphorylation
|
YAP1 |
0.327 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277649 |
Ser128 |
QHVRAHSsPASLQLG |
in vitro |
|
| pmid |
sentence |
| 29967145 |
CDK8 phosphorylates YAP and promotes its activation. Of interest, mutating four amino acid positions (T119, S128, S289, and S367) to alanines (YAP-4A) completely blocked phosphorylation (Fig. 6J), suggesting that CDK8 phosphorylates these sites in YAP in vitro. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277650 |
Ser289 |
PPPLAPQsPQGGVMG |
in vitro |
|
| pmid |
sentence |
| 29967145 |
CDK8 phosphorylates YAP and promotes its activation. Of interest, mutating four amino acid positions (T119, S128, S289, and S367) to alanines (YAP-4A) completely blocked phosphorylation (Fig. 6J), suggesting that CDK8 phosphorylates these sites in YAP in vitro. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277651 |
Ser367 |
GTQNPVSsPGMSQEL |
in vitro |
|
| pmid |
sentence |
| 29967145 |
CDK8 phosphorylates YAP and promotes its activation. Of interest, mutating four amino acid positions (T119, S128, S289, and S367) to alanines (YAP-4A) completely blocked phosphorylation (Fig. 6J), suggesting that CDK8 phosphorylates these sites in YAP in vitro. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277648 |
Thr119 |
AGTAGALtPQHVRAH |
in vitro |
|
| pmid |
sentence |
| 29967145 |
CDK8 phosphorylates YAP and promotes its activation. Of interest, mutating four amino acid positions (T119, S128, S289, and S367) to alanines (YAP-4A) completely blocked phosphorylation (Fig. 6J), suggesting that CDK8 phosphorylates these sites in YAP in vitro. |
|
| Publications: |
4 |
Organism: |
In Vitro |
| + |
NLK | up-regulates activity
phosphorylation
|
YAP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-273909 |
Ser128 |
QHVRAHSsPASLQLG |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 27979971 |
Here, we report that osmotic stress stimulates transient YAP nuclear localization and increases YAP activity even when YAP Ser127 is phosphorylated. Osmotic stress acts via the NLK kinase to induce YAP Ser128 phosphorylation. Phosphorylation of YAP at Ser128 interferes with its ability to bind to 14-3-3, resulting in YAP nuclear accumulation and induction of downstream target gene expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CyclinB/CDK1 | up-regulates activity
phosphorylation
|
YAP1 |
0.396 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276592 |
Ser138 |
SLQLGAVsPGTLTPT |
|
|
| pmid |
sentence |
| 26933062 |
Our evidence suggested that these YAP sites (Ser138, Thr143, and Ser367) were CDK1 phosphorylation sites.|These data demonstrate that the YAP phosphorylation sites Ser138, Thr143, and Ser367 are important for proper mitosis and cytokinesis. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276590 |
Ser367 |
GTQNPVSsPGMSQEL |
|
|
| pmid |
sentence |
| 26933062 |
Our evidence suggested that these YAP sites (Ser138, Thr143, and Ser367) were CDK1 phosphorylation sites.|These data demonstrate that the YAP phosphorylation sites Ser138, Thr143, and Ser367 are important for proper mitosis and cytokinesis. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276591 |
Thr143 |
AVSPGTLtPTGVVSG |
|
|
| pmid |
sentence |
| 26933062 |
Our evidence suggested that these YAP sites (Ser138, Thr143, and Ser367) were CDK1 phosphorylation sites.|These data demonstrate that the YAP phosphorylation sites Ser138, Thr143, and Ser367 are important for proper mitosis and cytokinesis. |
|
| Publications: |
3 |
| + |
CDK1 | up-regulates activity
phosphorylation
|
YAP1 |
0.434 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276589 |
Ser138 |
SLQLGAVsPGTLTPT |
|
|
| pmid |
sentence |
| 26933062 |
Our evidence suggested that these YAP sites (Ser138, Thr143, and Ser367) were CDK1 phosphorylation sites.|These data demonstrate that the YAP phosphorylation sites Ser138, Thr143, and Ser367 are important for proper mitosis and cytokinesis. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276587 |
Ser367 |
GTQNPVSsPGMSQEL |
|
|
| pmid |
sentence |
| 26933062 |
Our evidence suggested that these YAP sites (Ser138, Thr143, and Ser367) were CDK1 phosphorylation sites.|These data demonstrate that the YAP phosphorylation sites Ser138, Thr143, and Ser367 are important for proper mitosis and cytokinesis. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276588 |
Thr143 |
AVSPGTLtPTGVVSG |
|
|
| pmid |
sentence |
| 26933062 |
Our evidence suggested that these YAP sites (Ser138, Thr143, and Ser367) were CDK1 phosphorylation sites.|These data demonstrate that the YAP phosphorylation sites Ser138, Thr143, and Ser367 are important for proper mitosis and cytokinesis. |
|
| Publications: |
3 |
| + |
JNK | up-regulates activity
phosphorylation
|
YAP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277642 |
Ser138 |
SLQLGAVsPGTLTPT |
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 21364637 |
JNK phosphorylates YAP on multiple sites. The wild-type YAP (WT) and five mutant (T119A, S138A, T154A, S317A and T362A) Flag–YAP constructs were each transfected into U2OS cells |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277644 |
Ser367 |
GTQNPVSsPGMSQEL |
Homo sapiens |
|
| pmid |
sentence |
| 21364637 |
JNK phosphorylates YAP on multiple sites. The wild-type YAP (WT) and five mutant (T119A, S138A, T154A, S317A and T362A) Flag–YAP constructs were each transfected into U2OS cells |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277645 |
Ser400 |
SRDESTDsGLSMSSY |
Homo sapiens |
|
| pmid |
sentence |
| 21364637 |
JNK phosphorylates YAP on multiple sites. The wild-type YAP (WT) and five mutant (T119A, S138A, T154A, S317A and T362A) Flag–YAP constructs were each transfected into U2OS cells |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277641 |
Thr119 |
AGTAGALtPQHVRAH |
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 21364637 |
JNK phosphorylates YAP on multiple sites. The wild-type YAP (WT) and five mutant (T119A, S138A, T154A, S317A and T362A) Flag–YAP constructs were each transfected into U2OS cells |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277643 |
Thr154 |
VVSGPAAtPTAQHLR |
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 21364637 |
JNK phosphorylates YAP on multiple sites. The wild-type YAP (WT) and five mutant (T119A, S138A, T154A, S317A and T362A) Flag–YAP constructs were each transfected into U2OS cells |
|
| Publications: |
5 |
Organism: |
Homo Sapiens |
| + |
ULK1 | up-regulates quantity by stabilization
phosphorylation
|
YAP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277570 |
Ser227 |
VQQNMMNsASGPLPD |
Homo sapiens |
SW-1990 Cell |
| pmid |
sentence |
| 34345207 |
Mechanistically, hypoxia stimulates ULK1 to translocate into nucleus, where it interacts with and phosphorylates yes-associated protein (YAP) at Ser227, resulting in YAP stabilization through blockade of ubiquitin-proteasome system (UPS), which in turn facilitates PKM2 transcription, glycolysis, cell proliferation in vitro as well as PDAC growth in mice. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LATS1/2 | down-regulates quantity by destabilization
phosphorylation
|
YAP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277636 |
Ser397 |
TYHSRDEsTDSGLSM |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20048001 |
We show that YAP is phosphorylated by Lats on Ser 381 in one of the HXRXXS motifs, and this phosphorylation provides the priming signal for CK1delta/epsilon to phosphorylate a phosphodegron in YAP. The phosphorylated phosphodegron recruits beta-TRCP, leading to YAP ubiquitination and degradation under conditions of elevated Hippo pathway activity, such as cell contact inhibition |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo in cancer, Hippo Signaling, Integrin Signaling |
| + |
LATS2 | down-regulates quantity by destabilization
phosphorylation
|
YAP1 |
0.814 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-218038 |
Ser397 |
TYHSRDEsTDSGLSM |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20048001 |
We show that YAP is phosphorylated by Lats on Ser 381 in one of the HXRXXS motifs, and this phosphorylation provides the priming signal for CK1delta/epsilon to phosphorylate a phosphodegron in YAP. The phosphorylated phosphodegron recruits beta-TRCP, leading to YAP ubiquitination and degradation under conditions of elevated Hippo pathway activity, such as cell contact inhibition |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
LATS1 | down-regulates quantity by destabilization
phosphorylation
|
YAP1 |
0.834 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-218034 |
Ser397 |
TYHSRDEsTDSGLSM |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20048001 |
We show that YAP is phosphorylated by Lats on Ser 381 in one of the HXRXXS motifs, and this phosphorylation provides the priming signal for CK1delta/epsilon to phosphorylate a phosphodegron in YAP. The phosphorylated phosphodegron recruits beta-TRCP, leading to YAP ubiquitination and degradation under conditions of elevated Hippo pathway activity, such as cell contact inhibition |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
CSNK1D | down-regulates
phosphorylation
|
YAP1 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201143 |
Ser400 |
SRDESTDsGLSMSSY |
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
Phosphorylation of YAP (S381) and TAZ (S311) by Lats1/2 primes subsequent phosphorylation events by casein kinase 1 (CK1d/e); this sequential phosphorylation results in recruitment of b-transducin repeat-containing proteins (b-TRCP; a subunit of the SCF ubiquitin E3 ligase) and consequently leads to degradation of YAP/TAZ |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-230738 |
Ser400 |
SRDESTDsGLSMSSY |
Homo sapiens |
|
| pmid |
sentence |
| 24715453 |
LATS1/2-mediated phosphorylation of a conserved serine in this region (Ser311 in human TAZ; Ser397 in human YAP) primes for further phosphorylation by CK1_/_ kinases (Ser314 on human TAZ; Ser400/403 in human YAP) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-230743 |
Ser403 |
ESTDSGLsMSSYSVP |
Homo sapiens |
|
| pmid |
sentence |
| 24715453 |
LATS1/2-mediated phosphorylation of a conserved serine in this region (Ser311 in human TAZ; Ser397 in human YAP) primes for further phosphorylation by CK1_/_ kinases (Ser314 on human TAZ; Ser400/403 in human YAP) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201154 |
Ser403 |
ESTDSGLsMSSYSVP |
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
Phosphorylation of YAP (S381) and TAZ (S311) by Lats1/2 primes subsequent phosphorylation events by casein kinase 1 (CK1d/e); this sequential phosphorylation results in recruitment of b-transducin repeat-containing proteins (b-TRCP; a subunit of the SCF ubiquitin E3 ligase) and consequently leads to degradation of YAP/TAZ |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
CSNK1E | down-regulates
phosphorylation
|
YAP1 |
0.401 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201165 |
Ser400 |
SRDESTDsGLSMSSY |
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
Phosphorylation of YAP (S381) and TAZ (S311) by Lats1/2 primes subsequent phosphorylation events by casein kinase 1 (CK1d/e); this sequential phosphorylation results in recruitment of b-transducin repeat-containing proteins (b-TRCP; a subunit of the SCF ubiquitin E3 ligase) and consequently leads to degradation of YAP/TAZ |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-230728 |
Ser400 |
SRDESTDsGLSMSSY |
Homo sapiens |
|
| pmid |
sentence |
| 24715453 |
LATS1/2-mediated phosphorylation of a conserved serine in this region (Ser311 in human TAZ; Ser397 in human YAP) primes for further phosphorylation by CK1_/_ kinases (Ser314 on human TAZ; Ser400/403 in human YAP) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-230733 |
Ser403 |
ESTDSGLsMSSYSVP |
Homo sapiens |
|
| pmid |
sentence |
| 24715453 |
LATS1/2-mediated phosphorylation of a conserved serine in this region (Ser311 in human TAZ; Ser397 in human YAP) primes for further phosphorylation by CK1_/_ kinases (Ser314 on human TAZ; Ser400/403 in human YAP) |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201170 |
Ser403 |
ESTDSGLsMSSYSVP |
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
Phosphorylation of YAP (S381) and TAZ (S311) by Lats1/2 primes subsequent phosphorylation events by Casein Kinase 1 (CK1d/e); this sequential phosphorylation results in recruitment of b-transducin repeat-containing proteins (b-TRCP; a subunit of the SCF ubiquitin E3 ligase) and consequently leads to degradation of YAP/TAZ |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
IKBKE | down-regulates quantity by destabilization
phosphorylation
|
YAP1 |
0.45 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277355 |
Ser419 |
TPDDFLNsVDEMDTG |
Homo sapiens |
|
| pmid |
sentence |
| 28481329 |
Virus-activated kinase IKKɛ phosphorylated YAP at Ser403 and thereby triggered degradation of YAP in lysosomes and, consequently, relief of YAP-mediated inhibition of the cellular antiviral response. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
mTORC2 | up-regulates activity
phosphorylation
|
YAP1 |
0.284 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277569 |
Ser436 |
INQSTLPsQQNRFPD |
Homo sapiens |
U-87MG Cell |
| pmid |
sentence |
| 34343821 |
Here we report the ability of mTORC2 to directly phosphorylate YAP at serine 436 (Ser436) positively regulating YAP activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AMPK | down-regulates activity
phosphorylation
|
YAP1 |
0.304 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277638 |
Ser94 |
RLRKLPDsFFKPPEP |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 25751140 |
Moreover, AMPK directly phosphorylates YAP Ser 94, a residue essential for the interaction with TEAD, thus disrupting the YAP-TEAD interaction. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NEK2 | up-regulates quantity by stabilization
phosphorylation
|
YAP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276586 |
Thr143 |
AVSPGTLtPTGVVSG |
|
|
| pmid |
sentence |
| 35705994 |
NEK2 promotes the migration and proliferation of ESCC via stabilization of YAP1 by phosphorylation at Thr-143 |
|
| Publications: |
1 |
| + |
SRC | up-regulates activity
phosphorylation
|
YAP1 (isoform 3) |
0.616 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-274024 |
Tyr341 |
PFLNSGTyHSRDEST |
Mus musculus |
|
| pmid |
sentence |
| 27013234 |
We found that YAP1, the pivotal effector of the Hippo signaling pathway, is a direct SRC phosphorylation target, and YAP1 phosphorylation at three sites in its transcription activation domain is necessary for SRC-YAP1-mediated transformation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-274025 |
Tyr357 |
SGLSMSSySVPRTPD |
Mus musculus |
|
| pmid |
sentence |
| 27013234 |
We found that YAP1, the pivotal effector of the Hippo signaling pathway, is a direct SRC phosphorylation target, and YAP1 phosphorylation at three sites in its transcription activation domain is necessary for SRC-YAP1-mediated transformation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-274026 |
Tyr394 |
QQNRFPDyLEAIPGT |
Mus musculus |
|
| pmid |
sentence |
| 27013234 |
We found that YAP1, the pivotal effector of the Hippo signaling pathway, is a direct SRC phosphorylation target, and YAP1 phosphorylation at three sites in its transcription activation domain is necessary for SRC-YAP1-mediated transformation. |
|
| Publications: |
3 |
Organism: |
Mus Musculus |
| + |
FRK | down-regulates quantity by destabilization
phosphorylation
|
YAP1 |
0.278 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275455 |
Tyr391 |
PFLNSGTyHSRDEST |
Homo sapiens |
U-251MG Cell |
| pmid |
sentence |
| 35723276 |
Mechanistically, FRK interacted with and phosphorylated YAP on Tyr391/407/444, which recruited the classical E3 ubiquitin ligase Siah1 to catalyze ubiquitination and eventually degradation of YAP. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275456 |
Tyr407 |
SGLSMSSySVPRTPD |
Homo sapiens |
U-251MG Cell |
| pmid |
sentence |
| 35723276 |
Mechanistically, FRK interacted with and phosphorylated YAP on Tyr391/407/444, which recruited the classical E3 ubiquitin ligase Siah1 to catalyze ubiquitination and eventually degradation of YAP. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275457 |
Tyr444 |
QQNRFPDyLEAIPGT |
Homo sapiens |
U-251MG Cell |
| pmid |
sentence |
| 35723276 |
Mechanistically, FRK interacted with and phosphorylated YAP on Tyr391/407/444, which recruited the classical E3 ubiquitin ligase Siah1 to catalyze ubiquitination and eventually degradation of YAP. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
YES1 | up-regulates activity
phosphorylation
|
YAP1 |
0.71 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277652 |
Tyr391 |
PFLNSGTyHSRDEST |
Homo sapiens |
Hepatoma Cell Line |
| pmid |
sentence |
| 35041461 |
Yes directly phosphorylates YAP and TAZ, resulting in their increased nuclear localization and transcriptional activity.Analysis by mass spectrometry identified Tyr391 and Tyr407 as the two phosphorylation sites of YAP, whereas Tyr305 was the sole phosphorylated residue of TAZ (Fig. 5F and fig. S4, A to C). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277653 |
Tyr407 |
SGLSMSSySVPRTPD |
Homo sapiens |
Hepatoma Cell Line |
| pmid |
sentence |
| 35041461 |
Yes directly phosphorylates YAP and TAZ, resulting in their increased nuclear localization and transcriptional activity.Analysis by mass spectrometry identified Tyr391 and Tyr407 as the two phosphorylation sites of YAP, whereas Tyr305 was the sole phosphorylated residue of TAZ (Fig. 5F and fig. S4, A to C). |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
ABL1 | up-regulates
phosphorylation
|
YAP1 |
0.707 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-160860 |
Tyr407 |
SGLSMSSySVPRTPD |
Homo sapiens |
|
| pmid |
sentence |
| 18280240 |
In this study, we show that c-abl directly phosphorylates yap1 at position y357 in response to dna damage. Tyrosine-phosphorylated yap1 is a more stable protein that displays higher affinity to p73 and selectively coactivates p73 proapoptotic target genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AMOT/MPP5/INADL/LIN7C | down-regulates
binding
|
YAP1 |
0.363 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-170364 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 21145499 |
Because we found that multiple domains of taz/yap interacted with multiple components of the crumbs complex, which include pals1, lin7c, patj, and the crumbs regulator amot, we propose that this multifactoral interaction serves to ensure that assembly of the hippo pathway and efficient phosphorylation of taz/yap is coupled only by the assembly of the crumbs complex, rather than by any single component. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Hippo Signaling |
| + |
MYT1L | down-regulates quantity by repression
transcriptional regulation
|
YAP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266778 |
|
|
Homo sapiens |
Glioblastoma Multiforme Cell Line |
| pmid |
sentence |
| 30312684 |
Myt1 and Myt1l transcription factors limit proliferation in GBM cells by repressing YAP1 expression. Examination of the gene expression changes in cells expressing Myt1 or Myt1l suggests that both repress expression of the YAP1 transcriptional coactivator, which functions primarily in the Hippo signaling pathway. Expression of YAP1 and its target genes is reduced in Myt-expressing cells, and there is an inverse correlation between YAP1 and MYT1/MYT1L expression in human brain cancer datasets. Together, our data suggest that Myt1 and Myt1l directly repress expression of YAP1, a protein which promotes proliferation and GBM growth. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
α-Catenin | down-regulates activity
binding
|
YAP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265823 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
The trimeric complex of alfa-catenin, 14-3-3, and yap sequesters yap at ajs and prevents yap dephosphorylation/activation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265820 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
The trimeric complex of alfa-catenin, 14-3-3, and yap sequesters yap at ajs and prevents yap dephosphorylation/activation. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
YAP1 | up-regulates
binding
|
TEAD1 |
0.902 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201465 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
When dephosphorylated, yap/taz enter nuclei and induce gene transcription by interacting with transcription factors tead14. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YAP1 | up-regulates
binding
|
TEAD2 |
0.88 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201468 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
When dephosphorylated, yap/taz enter nuclei and induce gene transcription by interacting with transcription factors tead14. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YAP1 | up-regulates
binding
|
TEAD4 |
0.925 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201474 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
When dephosphorylated, yap/taz enter nuclei and induce gene transcription by interacting with transcription factors tead14. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YAP1 | up-regulates quantity by expression 
transcriptional regulation
|
TOP2A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276570 |
|
|
|
|
| pmid |
sentence |
| 30224758 |
By gene expression, exogenous YAP turns on its targets, but not in cells treated with JQ1 or depleted of BET-proteins (Fig. 3b and Supplementary Fig. 3e), indicating that BRD4 operates downstream of YAP/TAZ. |
|
| Publications: |
1 |
| Tissue: |
MCF-10A Cell |
| + |
YAP1 | up-regulates quantity by expression
transcriptional regulation
|
BMP4 |
0.323 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199066 |
|
|
Homo sapiens |
Myoblast, Satellite Cell |
| pmid |
sentence |
| 23038772 |
In our analysis bmp4 (bone morphogenetic protein 4) and fstl3 (follistatin-related protein 3) increased their expression in response to hyap1 s127a overexpression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
| + |
YAP1 | up-regulates quantity by expression
transcriptional regulation
|
KIF23 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276567 |
|
|
|
|
| pmid |
sentence |
| 30224758 |
By gene expression, exogenous YAP turns on its targets, but not in cells treated with JQ1 or depleted of BET-proteins (Fig. 3b and Supplementary Fig. 3e), indicating that BRD4 operates downstream of YAP/TAZ. |
|
| Publications: |
1 |
| Tissue: |
MCF-10A Cell |
| + |
YAP1 | up-regulates quantity by expression
transcriptional regulation
|
RRM2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276569 |
|
|
|
|
| pmid |
sentence |
| 30224758 |
By gene expression, exogenous YAP turns on its targets, but not in cells treated with JQ1 or depleted of BET-proteins (Fig. 3b and Supplementary Fig. 3e), indicating that BRD4 operates downstream of YAP/TAZ. |
|
| Publications: |
1 |
| Tissue: |
MCF-10A Cell |
| + |
YAP1 | down-regulates
binding
|
RUNX2 |
0.46 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195221 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22153608 |
Here we show that the endogenous yes-associated protein (yap), a mediator of src/yes signaling, interacts with the native runx2 protein, an osteoblast-related transcription factor, and suppresses runx2 transcriptional activity in a dose-dependent manner. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-121803 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14765127 |
Here we show that the endogenous yes-associated protein (yap), a mediator of src/yes signaling, interacts with the native runx2 protein, an osteoblast-related transcription factor, and suppresses runx2 transcriptional activity in a dose-dependent manner. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
SCF-betaTRCP | down-regulates quantity by destabilization
ubiquitination
|
YAP1 |
0.373 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217187 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
This cascade of phosphorylation allows the binding of scfbetatrcp that promotes the ubiquitination and degradation of yap. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
VEPH1 | up-regulates quantity by expression
transcriptional regulation
|
YAP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-202540 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 23989952 |
A double positive-feedback loop between melt and yki, wherein yki acti- vates melt expression, and melt promotes yki |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YAP1 | up-regulates quantity by expression
transcriptional regulation
|
TUBB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276571 |
|
|
|
|
| pmid |
sentence |
| 30224758 |
By gene expression, exogenous YAP turns on its targets, but not in cells treated with JQ1 or depleted of BET-proteins (Fig. 3b and Supplementary Fig. 3e), indicating that BRD4 operates downstream of YAP/TAZ. |
|
| Publications: |
1 |
| Tissue: |
MCF-10A Cell |
| + |
YAP1 | down-regulates 
|
FBXO32 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199069 |
|
|
Homo sapiens |
Myoblast, Satellite Cell |
| pmid |
sentence |
| 23038772 |
The downregulation of fbox32 expression by high yap activity in activated satellite cells may contribute to sustaining high levels of myod in activated satellite cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
| + |
BTRC | down-regulates
ubiquitination
|
YAP1 |
0.529 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201138 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
This cascade of phosphorylation allows the binding of scfbetatrcp that promotes the ubiquitination and degradation of yap. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YAP1 | down-regulates
|
MYF6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199075 |
|
|
Homo sapiens |
Myoblast, Satellite Cell |
| pmid |
sentence |
| 23038772 |
Myf6 (mrf4) is repressed by hyap1 s127a overexpression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
| + |
YAP1 | up-regulates quantity by expression
transcriptional regulation
|
CDC6 |
0.272 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276564 |
|
|
|
|
| pmid |
sentence |
| 30224758 |
By gene expression, exogenous YAP turns on its targets, but not in cells treated with JQ1 or depleted of BET-proteins (Fig. 3b and Supplementary Fig. 3e), indicating that BRD4 operates downstream of YAP/TAZ. |
|
| Publications: |
1 |
| Tissue: |
MCF-10A Cell |
| + |
YAP1 | up-regulates activity
binding
|
TEAD4 |
0.925 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277685 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33358571 |
The multifunctional cytokine TGF-β has been identified as a potent inducer of CTGF expression, activating CTGF transcription through the canonical Smad signaling pathway. It is worth noting that TGF-β synergizes with Hippo–Yes-associated protein (YAP) signaling, a key regulator of tumorigenesis, to induce the expression of CTGF by the formation of a YAP-TEAD4-Smad3-p300 complex on the CTGF promoter |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YAP1 | up-regulates
binding
|
TEAD3 |
0.845 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201471 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
When dephosphorylated, yap/taz enter nuclei and induce gene transcription by interacting with transcription factors tead14. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMAD3/SMAD4 | up-regulates activity
binding
|
YAP1 |
0.574 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277684 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 33358571 |
The multifunctional cytokine TGF-β has been identified as a potent inducer of CTGF expression, activating CTGF transcription through the canonical Smad signaling pathway. It is worth noting that TGF-β synergizes with Hippo–Yes-associated protein (YAP) signaling, a key regulator of tumorigenesis, to induce the expression of CTGF by the formation of a YAP-TEAD4-Smad3-p300 complex on the CTGF promoter |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YAP1 | up-regulates
binding
|
SMAD1 |
0.561 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201462 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
Yap binds to the phosphorylated smad1 to activate gene transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YAP1 | up-regulates quantity by expression
transcriptional regulation
|
CDCA5 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276565 |
|
|
|
|
| pmid |
sentence |
| 30224758 |
By gene expression, exogenous YAP turns on its targets, but not in cells treated with JQ1 or depleted of BET-proteins (Fig. 3b and Supplementary Fig. 3e), indicating that BRD4 operates downstream of YAP/TAZ. |
|
| Publications: |
1 |
| Tissue: |
MCF-10A Cell |
| + |
YAP1 | up-regulates
|
Proliferation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199217 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23075495 |
Yap and taz are two main downstream effectors of the hippo pathway, and they function as transcription co-activators to promote cell proliferation and inhibit apoptosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo in cancer, Hippo Signaling, Integrin Signaling |
| + |
YAP1 | up-regulates
|
YAP/TAZ |
0.533 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276572 |
|
|
|
|
| pmid |
sentence |
| 30224758 |
The transcription coactivators YAP/TAZ are ideal candidates to mediate cancer-specific transcriptional addictions. In fact, YAP/TAZ are genetically dispensable for homeostasis in many adult tissues9–17 while YAP/TAZ activation is a hallmark of many human malignancies13,17–19. Here we show that tumor transcriptional dependencies in fact overlap with tumor reliance on YAP/TAZ. |
|
| Publications: |
1 |
| + |
YAP1 | up-regulates
binding
|
TP73 |
0.705 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175934 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21808241 |
Yap also interacts with p73, a p53 family pro-apoptotic transcription factor, to induce expression of genes such as bax, puma and pml. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STXBP4 | down-regulates activity
binding
|
YAP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260013 |
|
|
in vitro |
|
| pmid |
sentence |
| 31782549 |
WW domain‐containing protein STXBP4 inhibits YAP activity via LATS1‐mediated phosphorylation. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
AMOT | down-regulates
relocalization
|
YAP1 |
0.727 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-175779 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21808241 |
Yap/taz and angiomotin (amot) family proteins were shown to interact, resulting in yap/taz localization to tight junctions and inhibition through phosphorylation-dependent and -independent mechanisms. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201135 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 21205866 |
Our results indicate a potential tumor-suppressing role of AMOT family proteins as components of the Hippo pathway, and demonstrate a novel mechanism of YAP and TAZ inhibition by AMOT-mediated tight junction localization. These observations provide a potential link between the Hippo pathway and cell contact inhibition. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
YAP1 | up-regulates quantity by expression
transcriptional regulation
|
GINS1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276566 |
|
|
|
|
| pmid |
sentence |
| 30224758 |
By gene expression, exogenous YAP turns on its targets, but not in cells treated with JQ1 or depleted of BET-proteins (Fig. 3b and Supplementary Fig. 3e), indicating that BRD4 operates downstream of YAP/TAZ. |
|
| Publications: |
1 |
| Tissue: |
MCF-10A Cell |
| + |
YAP1 | up-regulates activity
binding
|
TEAD |
0.94 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-230719 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
YAP/TAZ do not contain intrinsic DNA-binding domains but instead bind to the promoters of target genes by interacting with DNA-binding transcription factors. YAP/TAZ mainly bind to the transcription factors TEAD1–4 to regulate genes involved in cell proliferation and cell death |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo in cancer, Hippo Signaling, Integrin Signaling |
| + |
YAP1 | up-regulates quantity by expression
transcriptional regulation
|
FSTL3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199072 |
|
|
Homo sapiens |
Myoblast, Satellite Cell |
| pmid |
sentence |
| 23038772 |
In our analysis bmp4 (bone morphogenetic protein 4) and fstl3 (follistatin-related protein 3) increased their expression in response to hyap1 s127a overexpression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
| + |
YAP1 | up-regulates quantity by expression
transcriptional regulation
|
SGK1 |
0.284 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276585 |
|
|
|
|
| pmid |
sentence |
| 35216681 |
Importantly, YAP-dependent regulation of serum- and glucocorticoid-regulated kinase 1 (SGK1) is required to activate mTORC1/SREBP and stimulate de novo lipogenesis. |
|
| Publications: |
1 |
| + |
YAP1 | down-regulates
binding
|
DVL1 |
0.339 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199806 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23178811 |
Yap restricts elevated wnt independently of the axinapcgsk-3beta complex partly by limiting the activity of dishevelled (dvl). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYT1 | down-regulates quantity by repression
transcriptional regulation
|
YAP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266777 |
|
|
Homo sapiens |
Glioblastoma Multiforme Cell Line |
| pmid |
sentence |
| 30312684 |
Myt1 and Myt1l transcription factors limit proliferation in GBM cells by repressing YAP1 expression. Examination of the gene expression changes in cells expressing Myt1 or Myt1l suggests that both repress expression of the YAP1 transcriptional coactivator, which functions primarily in the Hippo signaling pathway. Expression of YAP1 and its target genes is reduced in Myt-expressing cells, and there is an inverse correlation between YAP1 and MYT1/MYT1L expression in human brain cancer datasets. Together, our data suggest that Myt1 and Myt1l directly repress expression of YAP1, a protein which promotes proliferation and GBM growth. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CTNNA2 | down-regulates
binding
|
YAP1 |
0.335 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201245 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
The trimeric complex of alfa-catenin, 14-3-3, and yap sequesters yap at ajs and prevents yap dephosphorylation/activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CTNNA1 | down-regulates
binding
|
YAP1 |
0.36 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201173 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
The trimeric complex of alfa-catenin, 14-3-3, and yap sequesters yap at ajs and prevents yap dephosphorylation/activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
YAP1 | up-regulates quantity by expression
transcriptional regulation
|
CCNA2 |
0.329 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276563 |
|
|
|
|
| pmid |
sentence |
| 30224758 |
By gene expression, exogenous YAP turns on its targets, but not in cells treated with JQ1 or depleted of BET-proteins (Fig. 3b and Supplementary Fig. 3e), indicating that BRD4 operates downstream of YAP/TAZ. |
|
| Publications: |
1 |
| Tissue: |
MCF-10A Cell |
| + |
14-3-3 | down-regulates
binding
|
YAP1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-169719 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21084559 |
Phosphorylation of yap ser127 and of the corresponding sites in yki and taz generates a protein-binding motif for the 14-3-3 family proteins, which, upon binding by a 14-3-3 protein, leads to their cytoplasmic retention. One protein that associates with 14-3-3 in an akt-dependent manner is shown here to be the yes-associated protein (yap), which is phosphorylated by akt at serine 127, leading to binding to 14-3-3. Akt promotes yap localization to the cytoplasm, resulting in loss from the nucleus where it functions as a coactivator of transcription factors including p73. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-97481 |
|
|
Chlorocebus aethiops |
COS Cell |
| pmid |
sentence |
| 12535517 |
One protein that associates with 14-3-3 in an akt-dependent manner is shown here to be the yes-associated protein (yap), which is phosphorylated by akt at serine 127, leading to binding to 14-3-3. Akt promotes yap localization to the cytoplasm, resulting in loss from the nucleus where it functions as a coactivator of transcription factors including p73. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, Chlorocebus Aethiops |
| Pathways: | Hippo Signaling |
| + |
dobutamine | down-regulates
|
YAP1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201259 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
Dobutamine is an agonist for the beta1 adrenergic receptor, which likely inhibits yap by activating gaalfas. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YAP1 | down-regulates
|
Cell_death |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256669 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23075495 |
Yap and taz are two main downstream effectors of the hippo pathway, and they function as transcription co-activators to promote cell proliferation and inhibit apoptosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YAP1 | down-regulates
|
Apoptosis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199214 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23075495 |
Yap and taz are two main downstream effectors of the hippo pathway, and they function as transcription co-activators to promote cell proliferation and inhibit apoptosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo in cancer, Hippo Signaling, Integrin Signaling |
| + |
YAP1 | up-regulates quantity by expression
transcriptional regulation
|
WWC1 |
0.372 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263660 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21233212 |
We also found that KIBRA mRNA is induced by YAP overexpression in both murine and human cells, suggesting the evolutionary conservation of KIBRA as a transcriptional target of the Hippo signaling pathway. Thus, our study revealed a new connection between KIBRA and mammalian Hippo signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
YAP1 | up-regulates quantity by expression
transcriptional regulation
|
SLC2A1 |
0.262 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276584 |
|
|
|
|
| pmid |
sentence |
| 30348863 |
Transcriptomic and metabolomic analyses reveal that Yap regulates expression of glucose transporter glut1, causing decreased glucose uptake and use for nucleotide biosynthesis in yap-/- mutants, and impaired glucose tolerance in adults. |
|
| Publications: |
1 |
| + |
TJP2 | down-regulates
binding
|
YAP1 |
0.499 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-230754 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23829894 |
The Crumbs complex component AMOT co-localizes with MST1_ 2, LATS1_ 2 and YAP in a complex at the tight junction to control cell growth. Zona occludens-2 (ZO-2) in the tight junction, and a-catenin, b-catenin, or PTPN14 in the adherence junction, also bind to YAP_TAZ. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo Signaling |
| + |
YAP1 | up-regulates quantity by expression
transcriptional regulation
|
MCM3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276568 |
|
|
|
|
| pmid |
sentence |
| 30224758 |
By gene expression, exogenous YAP turns on its targets, but not in cells treated with JQ1 or depleted of BET-proteins (Fig. 3b and Supplementary Fig. 3e), indicating that BRD4 operates downstream of YAP/TAZ. |
|
| Publications: |
1 |
| Tissue: |
MCF-10A Cell |
| + |
YAP1 | up-regulates
binding
|
CTNNB1 |
0.546 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201939 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23607968 |
Additionally, the hippo and wnts also cooperate in the nucleus, where yap interacts with beta-catenin and induces the expression of canonical wnt target genes, such as sox2 and snai2 in mouse heart tissue. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Heart |
3.0
YAP1
- 
- 