3.0
Summary
| Name |  FSTL3
|
| Full Name | Follistatin-related protein 3 |
| Synonyms | Follistatin-like protein 3, Follistatin-related gene protein | FLRG |
| Primary ID | O95633 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10. |
Viewer
Search Tools
Refine search:
- by mechanism
- by effect
- by organism:
- by tissue:
- by cell-line
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | FSTL3 | down-regulates 
binding
|
MSTN | 0.696 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Muscle, Skeletal Muscle | |||
| + | YAP1 | up-regulates quantity by expression 
transcriptional regulation
|
FSTL3 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Muscle, Skeletal Muscle | |||