| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277711 |
|
|
Homo sapiens |
Th2 Cell |
| pmid |
sentence |
| 16286016 |
We report a member of the IL-1 family, IL-33, which mediates its biological effects via IL-1 receptor ST 2, activates NF-kappaB and MAP kinases, and drives production of T(H)2-associated cytokines from in vitro polarized T(H)2 cells. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs.The binding of IL-33 to cells that express ST2 results in the activation of NF-κB and MAP kinases. Administration of purified IL-33 either in vitro or in vivo leads to the production of TH2-associated cytokines. |
|
3.0
IL33
- 
- 
binding