| + |
IL33 | up-regulates activity 
binding
|
IL1RL1 |
0.923 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277711 |
|
|
Homo sapiens |
Th2 Cell |
| pmid |
sentence |
| 16286016 |
We report a member of the IL-1 family, IL-33, which mediates its biological effects via IL-1 receptor ST 2, activates NF-kappaB and MAP kinases, and drives production of T(H)2-associated cytokines from in vitro polarized T(H)2 cells. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs.The binding of IL-33 to cells that express ST2 results in the activation of NF-κB and MAP kinases. Administration of purified IL-33 either in vitro or in vivo leads to the production of TH2-associated cytokines. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL1RL1 | up-regulates activity
binding
|
IL1RAP |
0.517 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277715 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 35238669 |
The initial step in IL-33 signal transduction is ligand-induced conformational changes in IL-33R, which facilitate recruitment of interleukin-1 receptor accessory protein (IL-1RAP). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL1RL1 | up-regulates activity
binding
|
MAP3K7 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277716 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 35238669 |
The activated heterodimer complex recruits downstream signaling components, including myeloid differentiation primary response protein 88 (MyD88), IL-1 receptor (IL-1R)–associated kinase, tumor necrosis factor (TNF) receptor–associated factor 6 (TRAF6), and transforming growth factor (TGF)-β–activated kinase 1 (TAK1) complex, resulting in TAK1 activation. TAK1 subsequently activates downstream kinases inhibitor of nuclear factor kappa-B kinase subunit alpha (IKKα) and IKKβ, which phosphorylate nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) inhibitor (IκB) proteins. These events ultimately lead to activation of the transcription factor NF-κB and induction of downstream effector genes |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL1RL1 | up-regulates activity
binding
|
IRAK1 |
0.587 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277706 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16286016 |
As shown in Figure 3D, MyD88, IRAK, IRAK4, and TRAF6 are all recruited to ST2 upon IL-33 stimulation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL1RL1 | up-regulates activity
binding
|
MYD88 |
0.641 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277704 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16286016 |
As shown in Figure 3D, MyD88, IRAK, IRAK4, and TRAF6 are all recruited to ST2 upon IL-33 stimulation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL1RL1 | up-regulates activity
binding
|
IRAK4 |
0.587 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277705 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16286016 |
As shown in Figure 3D, MyD88, IRAK, IRAK4, and TRAF6 are all recruited to ST2 upon IL-33 stimulation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL1RL1 | up-regulates activity
binding
|
TRAF6 |
0.577 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277707 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 16286016 |
As shown in Figure 3D, MyD88, IRAK, IRAK4, and TRAF6 are all recruited to ST2 upon IL-33 stimulation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
IL1RL1
- 
- 