Summary

Name GPR75
Full Name Probable G protein-coupled receptor 75
Synonyms |
Primary ID O95800
Links - -
Type protein
Relations 1
Function G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor. {ECO:0000250|UniProtKB:Q6X632, ECO:0000303|PubMed:23979485}.

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Relations

Regulator Mechanism target score ℹ
+ GPR75up-regulates activity img/direct-activation.png binding GNAI1
Publications: 1 Organism: Homo Sapiens