Summary

Name EOMES
Full Name Eomesodermin homolog
Synonyms T-box brain protein 2, T-brain-2, TBR-2 | TBR2
Primary ID O95936
Links - -
Type protein
Relations 1
Function Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes.

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Relations

Regulator Mechanism target score ℹ
+ POU5F1down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation EOMES 0.434
Publications: 1 Organism: Homo Sapiens