Relation Results

Summary

Name CCNE2
Full Name G1/S-specific cyclin-E2
Synonyms CCNE2_HUMAN
Primary ID O96020
Links - -
Type protein
Relations 6
Function Essential for the control of the cell cycle at the late G1 and early S phase.

Viewer

Type: Score: Layout: SPV 
0.420.9340.4380.510.20.574CHD8CCNE2CyclinE/CDK2FBXW7Cullin 1-RBX1-Skp1MYCT1SCF-SKP2

Search Tools

Refine search:

  • by mechanism


  • by effect
  • by organism:


  • by tissue:


  • by cell-line

Relations
Regulator
Mechanism
target
score ℹ
+ CHD8up-regulates quantity by expression img/direct-activation.png transcriptional regulation CCNE2 0.42
Identifier Residue Sequence Organism Cell Line
SIGNOR-268804 Homo sapiens HeLa Cell
pmid sentence
In order to identify CHD8 target genes, we performed a transcriptomic analysis of CHD8-depleted cells, finding out that CHD8 controls the expression of cyclin E2 (CCNE2) and thymidylate synthetase (TYMS), two genes expressed in the G1/S transition of the cell cycle. CHD8 was also able to co-activate the CCNE2 promoter in transient transfection experiments. Chromatin immunoprecipitation experiments demonstrated that CHD8 binds directly to the 5' region of both CCNE2 and TYMS genes.
Publications: 1 Organism: Homo Sapiens
+ CCNE2form complex img/form-complex.png binding CyclinE/CDK2 0.934
Identifier Residue Sequence Organism Cell Line
SIGNOR-187454 Homo sapiens
pmid sentence
The eukaryotic cell cycle is controlled by different cyclins and their associated kinases (murray and hunt, 1993). In mammalian cells, levels of cycline and its associated kinase, cdk2, rise in late g1/early s-phase when dna replication is initiated
Publications: 1 Organism: Homo Sapiens
+ FBXW7down-regulates quantity by destabilization img/direct_inhibition.png binding CCNE2 0.438
Identifier Residue Sequence Organism Cell Line
SIGNOR-271642 Homo sapiens HEK-293A Cell
pmid sentence
Cdk2 (S384) and GSK3 (T380) prime cyclin E for destruction. The hyper-phosphorylated T380/S384 degron has high affinity for monomeric Fbw7α, which engages the remainder of the SCF to initiate cyclin E's ubiquitination by an E2 enzyme
Publications: 1 Organism: Homo Sapiens
+ Cullin 1-RBX1-Skp1down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination CCNE2 0.51
Identifier Residue Sequence Organism Cell Line
SIGNOR-271638 Homo sapiens HEK-293A Cell
pmid sentence
Cdk2 (S384) and GSK3 (T380) prime cyclin E for destruction. The hyper-phosphorylated T380/S384 degron has high affinity for monomeric Fbw7α, which engages the remainder of the SCF to initiate cyclin E's ubiquitination by an E2 enzyme
Publications: 1 Organism: Homo Sapiens
+ MYCT1down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CCNE2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-261733 Homo sapiens
pmid sentence
MYCT1 overexpression significantly inhibited cell proliferation, arrested cell cycle at G0/G1 phase, and downregulated the expression of cyclins D and E. Moreover, MYCT1 overexpression triggered apoptosis in AML cells, which was accompanied by enhanced cleavage of caspase-3 and -9, upregulated expression of B-cell lymphoma 2 (Bcl-2)-associated X protein (Bax), and downregulated Bcl-2.
Publications: 1 Organism: Homo Sapiens
+ SCF-SKP2down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination CCNE2 0.574
Identifier Residue Sequence Organism Cell Line
SIGNOR-267559 in vitro
pmid sentence
The amount of cyclin E protein present in the cell is tightly controlled by ubiquitin-mediated proteolysis. Here we identify the ubiquitin ligase responsible for cyclin E ubiquitination as SCFFbw7 and demonstrate that it is functionally conserved in yeast, flies, and mammals. Fbw7 associates specifically with phosphorylated cyclin E, and SCFFbw7 catalyzes cyclin E ubiquitination in vitro
Publications: 1 Organism: In Vitro
a simple tooltip