| + |
CHD8 | up-regulates quantity by expression 
transcriptional regulation
|
CCNE2 |
0.429 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268804 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 19255092 |
In order to identify CHD8 target genes, we performed a transcriptomic analysis of CHD8-depleted cells, finding out that CHD8 controls the expression of cyclin E2 (CCNE2) and thymidylate synthetase (TYMS), two genes expressed in the G1/S transition of the cell cycle. CHD8 was also able to co-activate the CCNE2 promoter in transient transfection experiments. Chromatin immunoprecipitation experiments demonstrated that CHD8 binds directly to the 5' region of both CCNE2 and TYMS genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Cullin 1-RBX1-Skp1 | down-regulates quantity by destabilization 
polyubiquitination
|
CCNE2 |
0.495 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271638 |
|
|
Homo sapiens |
HEK-293A Cell |
| pmid |
sentence |
| 17298674 |
Cdk2 (S384) and GSK3 (T380) prime cyclin E for destruction. The hyper-phosphorylated T380/S384 degron has high affinity for monomeric Fbw7α, which engages the remainder of the SCF to initiate cyclin E's ubiquitination by an E2 enzyme |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYCT1 | down-regulates quantity by repression 
transcriptional regulation
|
CCNE2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261733 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30283340 |
MYCT1 overexpression significantly inhibited cell proliferation, arrested cell cycle at G0/G1 phase, and downregulated the expression of cyclins D and E. Moreover, MYCT1 overexpression triggered apoptosis in AML cells, which was accompanied by enhanced cleavage of caspase-3 and -9, upregulated expression of B-cell lymphoma 2 (Bcl-2)-associated X protein (Bax), and downregulated Bcl-2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CCNE2 | form complex 
binding
|
CyclinE/CDK2 |
0.931 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-187454 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19665013 |
The eukaryotic cell cycle is controlled by different cyclins and their associated kinases (murray and hunt, 1993). In mammalian cells, levels of cycline and its associated kinase, cdk2, rise in late g1/early s-phase when dna replication is initiated |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SCF-SKP2 | down-regulates quantity by destabilization
ubiquitination
|
CCNE2 |
0.558 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267559 |
|
|
in vitro |
|
| pmid |
sentence |
| 11533444 |
The amount of cyclin E protein present in the cell is tightly controlled by ubiquitin-mediated proteolysis. Here we identify the ubiquitin ligase responsible for cyclin E ubiquitination as SCFFbw7 and demonstrate that it is functionally conserved in yeast, flies, and mammals. Fbw7 associates specifically with phosphorylated cyclin E, and SCFFbw7 catalyzes cyclin E ubiquitination in vitro |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
FBXW7 | down-regulates quantity by destabilization
binding
|
CCNE2 |
0.447 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271642 |
|
|
Homo sapiens |
HEK-293A Cell |
| pmid |
sentence |
| 17298674 |
Cdk2 (S384) and GSK3 (T380) prime cyclin E for destruction. The hyper-phosphorylated T380/S384 degron has high affinity for monomeric Fbw7α, which engages the remainder of the SCF to initiate cyclin E's ubiquitination by an E2 enzyme |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CCNE2
- 
- 