4.0
Summary
| Name |  GLUD1View Modifications |
| Full Name | Glutamate dehydrogenase 1, mitochondrial |
| Synonyms | GDH 1 | GLUD |
| Primary ID | P00367 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Pathways | Glutamine metabolism |
| Function | Mitochondrial glutamate dehydrogenase that catalyzes the conversion of L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (PubMed:11032875, PubMed:16959573, PubMed:11254391, PubMed:16023112). Plays a role in insulin homeostasis (PubMed:9571255, PubMed:11297618). May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | EGFR | up-regulates activity 
phosphorylation
|
GLUD1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | GLUD1 | down-regulates quantity 
chemical modification
|
glutamic acid | 0.8 |
| Publications: | 1 | Organism: | Bos Taurus | |
| + | GLUD1 | up-regulates quantity
chemical modification
|
2-oxoglutarate(2-) | 0.8 |
| Publications: | 1 | Organism: | Bos Taurus | |
| Pathways: | Glutamine metabolism | |||
| + | SIRT4 | down-regulates activity
glycosylation
|
GLUD1 | 0.622 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Glutamine metabolism | |||
| + | RIPK3 | up-regulates
binding
|
GLUD1 | 0.448 |
| Publications: | 1 | Organism: | Homo Sapiens | |