Summary

Name GLUD1
Full Name Glutamate dehydrogenase 1, mitochondrial
Synonyms GDH 1 | GLUD
Primary ID P00367
Links - -
Type protein
Relations 4
Pathways Glutamine metabolism
Function Mitochondrial glutamate dehydrogenase that catalyzes the conversion of L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (PubMed:11032875, PubMed:16959573, PubMed:11254391, PubMed:16023112). Plays a role in insulin homeostasis (PubMed:9571255, PubMed:11297618). May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity).

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Relations

Regulator Mechanism target score ℹ
+ RIPK3up-regulates img/direct-activation.png binding GLUD1 0.426
Publications: 1 Organism: Homo Sapiens
+ GLUD1up-regulates quantity img/direct-activation.png chemical modification 2-oxoglutarate(2-) 0.8
Publications: 1 Organism: Bos Taurus
Pathways:Glutamine metabolism
+ SIRT4down-regulates activity img/direct_inhibition.png glycosylation GLUD1 0.604
Publications: 1 Organism: Homo Sapiens
Pathways:Glutamine metabolism
+ GLUD1down-regulates quantity img/direct_inhibition.png chemical modification glutamic acid 0.8
Publications: 1 Organism: Bos Taurus