+ |
SHH | down-regulates
binding
|
CP |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-154285 |
|
|
Homo sapiens |
|
pmid |
sentence |
17419683 |
Binding of sonic hedgehog (shh) to patched (ptc) relieves the latter's tonic smoothened (smo), a receptor that spans the cell membrane seven times. Ptch exists in vertebrates as two isoforms, ptch1 and ptch2, which seem to be equivalent in terms of binding the three hh isoforms. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-132672 |
|
|
Homo sapiens |
|
pmid |
sentence |
15618519 |
Binding of sonic hedgehog (shh) to patched (ptc) relieves the latter's tonic smoothened (smo), a receptor that spans the cell membrane seven times. Ptch exists in vertebrates as two isoforms, ptch1 and ptch2, which seem to be equivalent in terms of binding the three hh isoforms. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-118612 |
|
|
Homo sapiens |
|
pmid |
sentence |
14556242 |
Two genes were newly identified to be shh responsive in neuroepithelial cell line mns-70: the metal-binding protein ceruloplasmin (cp) and the serine protease inhibitor inter-alpha-trypsine inhibitor heavy chain h3 (itih3). cp appeared to be regulated by gli-independent pathways. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-61549 |
|
|
Homo sapiens |
|
pmid |
sentence |
9811851 |
Binding of sonic hedgehog (shh) to patched (ptc) relieves the latter's tonic smoothened (smo), a receptor that spans the cell membrane seven times. Ptch exists in vertebrates as two isoforms, ptch1 and ptch2, which seem to be equivalent in terms of binding the three hh isoforms. |
|
Publications: |
4 |
Organism: |
Homo Sapiens |
Tissue: |
Skin |
+ |
CP | down-regulates
binding
|
SMO |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-148451 |
|
|
Homo sapiens |
|
pmid |
sentence |
16885213 |
Genetic and biochemical studies imply that smo can adopt an active conformation but that it is normally repressed by patched (ptch), a 12-transmembrane protein considered the receptor for hh |
|
Publications: |
1 |
Organism: |
Homo Sapiens |