4.0
Summary
| Name |  PGK1View Modifications |
| Full Name | Phosphoglycerate kinase 1 |
| Synonyms | Cell migration-inducing gene 10 protein, Primer recognition protein 2, PRP 2 | PGKA |
| Primary ID | P00558 |
| Links |  -  -  |
| Type | protein |
| Relations | 7 |
| Function | Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate (PubMed:30323285, PubMed:7391028). In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein) (PubMed:2324090). May play a role in sperm motility (PubMed:26677959). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PDPK1 | up-regulates activity 
phosphorylation
|
PGK1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PGK1 | up-regulates activity
phosphorylation
|
PDK1 | 0.43 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Glycolysis and Gluconeogenesis | |||
| + | PGK1 | up-regulates activity
phosphorylation
|
PGK1 | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |
| Pathways: | Glycolysis and Gluconeogenesis | |||
| + | PGK1 | up-regulates quantity
chemical modification
|
3-phosphonato-D-glycerate(3-) | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Glycolysis and Gluconeogenesis | |||
| + | PGK1 | up-regulates activity
phosphorylation
|
PDPK1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | HIF1A | up-regulates quantity by expression 
transcriptional regulation
|
PGK1 | 0.469 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PGK1 | down-regulates quantity 
chemical modification
|
3-phosphonato-D-glyceroyl phosphate(4-) | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Glycolysis and Gluconeogenesis | |||