Relation Results

Summary

Name PGK1
Full Name Phosphoglycerate kinase 1
Synonyms Cell migration-inducing gene 10 protein, Primer recognition protein 2, PRP 2 | PGKA
Primary ID P00558
Links - -
Type protein
Relations 5
Function Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycera ...
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Type: Score: Layout: SPV 
0.20.20.80.4810.8PDPK1PGK13-phosphonato-D-glyceroyl phosphate(4-)HIF1A3-phosphonato-D-glycerate(3-)

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ PDPK1up-regulates activity img/direct-activation.png phosphorylation PGK1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-277402 Thr243 IGGGMAFtFLKVLNN Homo sapiens U-87MG Cell
pmid sentence
PDPK1 Phosphorylates PGK1 T243. Macrophages increase PGK1 pT243 to reduce the 3-PG affinity of PGK1, which alters the equilibrium of the PGK1-catalyzed reaction toward glycolysis, promoting tumor cell proliferation.
Publications: 1 Organism: Homo Sapiens
+ PGK1up-regulates activity img/direct-activation.png phosphorylation PGK1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-277482 Tyr324 GPESSKKyAEAVTRA in vitro
pmid sentence
PGK1 functions not only as a glycolytic enzyme but also as a protein kinase intermolecularly autophosphorylating itself at Y324 for activation. 
Publications: 1 Organism: In Vitro
Pathways:Glycolysis and Gluconeogenesis
+ PGK1down-regulates quantity img/direct_inhibition.png chemical modification 3-phosphonato-D-glyceroyl phosphate(4-) 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-266502 Homo sapiens
pmid sentence
Phosphoglycerate kinase generates one molecule of ATP by catalyzing the reversible conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate. Two isozymes of PGK exist: PGK-1, ubiquitously expressed in all somatic cells, and PGK-2, expressed only in spermatozoa.
Publications: 1 Organism: Homo Sapiens
Pathways:Glycolysis and Gluconeogenesis
+ HIF1Aup-regulates quantity by expression img/indirect-activation.png transcriptional regulation PGK1 0.481
Identifier Residue Sequence Organism Cell Line
SIGNOR-254424 Homo sapiens HeLa Cell, HEP-3B Cell
pmid sentence
Hypoxia-inducible factor 1 (HIF-1) activates erythropoietin gene transcription in Hep3B cells subjected to hypoxia. HIF-1 activity is also induced by hypoxia in non-erythropoietin-producing cells, suggesting a more general regulatory role. We now report that RNAs encoding the glycolytic enzymes aldolase A (ALDA), phosphoglycerate kinase 1 (PGK1), and pyruvate kinase M were induced by exposure of Hep3B or HeLa cells to inducers of HIF-1 (1% O2, cobalt chloride, or desferrioxamine). Sequences from the ALDA, PFKL, and PGK1 genes containing HIF-1 binding sites mediated hypoxia-inducible transcription in transient expression assays.
Publications: 1 Organism: Homo Sapiens
+ PGK1up-regulates quantity img/direct-activation.png chemical modification 3-phosphonato-D-glycerate(3-) 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-266505 Homo sapiens
pmid sentence
Phosphoglycerate kinase generates one molecule of ATP by catalyzing the reversible conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate. Two isozymes of PGK exist: PGK-1, ubiquitously expressed in all somatic cells, and PGK-2, expressed only in spermatozoa.
Publications: 1 Organism: Homo Sapiens
Pathways:Glycolysis and Gluconeogenesis
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