+ |
CFD | up-regulates activity
cleavage
|
CFB |
0.796 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-263487 |
Arg259 |
GPGEQQKrKIVLDPS |
Homo sapiens |
|
pmid |
sentence |
26489954 |
The resulting proconvertase C3bB is subsequently cleaved by factor D (FD), generating the AP C3 convertase C3bBb |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-263488 |
Thr25 |
LLSGGVTtTPWSLAR |
Homo sapiens |
|
pmid |
sentence |
26489954 |
The resulting proconvertase C3bB is subsequently cleaved by factor D (FD), generating the AP C3 convertase C3bBb |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
Tissue: |
Blood |
+ |
CFB | form complex
binding
|
C3 convertase complex (C3bBb) |
0.903 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-263486 |
|
|
Homo sapiens |
|
pmid |
sentence |
26489954 |
Surface‐associated C3b recruits FB, which leads to FB activation and the formation of C3bBb, the AP C3 convertase, which cleaves more C3 and amplifies complement activation. In addition to the surface‐bound C3 convertase, a fluid‐phase convertase can be formed by association of water‐reacted C3, termed C3(H20), to FB thus constantly maintaining a low level of complement activation in solution (tick‐over) |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Tissue: |
Blood |
+ |
CREB5 | up-regulates quantity by expression
transcriptional regulation
|
CFB |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-253802 |
|
|
Homo sapiens |
|
pmid |
sentence |
21132541 |
Our result verified CREB5 biological regulation module in the upstream of frontal cortex of HIVE-control patients (MAPKAPK3 activation; DGKG, LY96, TNFRSF11B inhibition) and downstream (ATP6V0E1, CFB, DGKG, MX1, TGFBR3 activation; LGALS3BP, RASGRP3, RDX, STAT1 inhibition), |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Tissue: |
L-6 Myoblast Cell |
+ |
CFH | down-regulates activity
binding
|
CFB |
0.497 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-252142 |
|
|
Homo sapiens |
|
pmid |
sentence |
19050261 |
As a regulator of the alternative pathway, FH binds to C3b and inhibits the binding of factor B to C3b, acts as a cofactor for the factor I-mediated cleavage of C3b to iC3b (cofactor activity), and accelerates the decay of C3bBb, the alternative pathway C3 convertase (decay-accelerating activity) |
|
Publications: |
1 |
Organism: |
Homo Sapiens |