| + |
C3 convertase complex (C3bBb) | up-regulates activity 
cleavage
|
C3 |
0.903 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263477 |
Arg671 |
QPAARRRrSVQLTEK |
Homo sapiens |
|
| pmid |
sentence |
| 26489954 |
In addition to the surface‐bound C3 convertase, a fluid‐phase convertase can be formed by association of water‐reacted C3, termed C3(H20), to FB thus constantly maintaining a low level of complement activation in solution (tick‐over). Both of the surface‐bound C3 convertases can bind a C3b molecule whereby the C5 convertases are formed. These cleave C5 into C5a and C5b, thus initiating the terminal pathway and leading to formation of the membrane attack complex (MAC). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263478 |
Arg748 |
ASHLGLArSNLDEDI |
Homo sapiens |
|
| pmid |
sentence |
| 26489954 |
In addition to the surface‐bound C3 convertase, a fluid‐phase convertase can be formed by association of water‐reacted C3, termed C3(H20), to FB thus constantly maintaining a low level of complement activation in solution (tick‐over). Both of the surface‐bound C3 convertases can bind a C3b molecule whereby the C5 convertases are formed. These cleave C5 into C5a and C5b, thus initiating the terminal pathway and leading to formation of the membrane attack complex (MAC). |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Blood |
| + |
C3 convertase complex (C3bBb) | form complex 
binding
|
C5 convertase complex (C3bBbC3b) |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263479 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26489954 |
In addition to the surface‐bound C3 convertase, a fluid‐phase convertase can be formed by association of water‐reacted C3, termed C3(H20), to FB thus constantly maintaining a low level of complement activation in solution (tick‐over). Both of the surface‐bound C3 convertases can bind a C3b molecule whereby the C5 convertases are formed. These cleave C5 into C5a and C5b, thus initiating the terminal pathway and leading to formation of the membrane attack complex (MAC). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Blood |
| + |
C3 | form complex
binding
|
C3 convertase complex (C3bBb) |
0.903 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263485 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26489954 |
Surface‐associated C3b recruits FB, which leads to FB activation and the formation of C3bBb, the AP C3 convertase, which cleaves more C3 and amplifies complement activation. In addition to the surface‐bound C3 convertase, a fluid‐phase convertase can be formed by association of water‐reacted C3, termed C3(H20), to FB thus constantly maintaining a low level of complement activation in solution (tick‐over) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Blood |
| + |
CFB | form complex
binding
|
C3 convertase complex (C3bBb) |
0.903 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263486 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26489954 |
Surface‐associated C3b recruits FB, which leads to FB activation and the formation of C3bBb, the AP C3 convertase, which cleaves more C3 and amplifies complement activation. In addition to the surface‐bound C3 convertase, a fluid‐phase convertase can be formed by association of water‐reacted C3, termed C3(H20), to FB thus constantly maintaining a low level of complement activation in solution (tick‐over) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Blood |
3.0
C3 convertase complex (C3bBb)
CPX-5601