| + |
APOB | up-regulates 
binding
|
LDLR |
0.798 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-87035 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11986215 |
In the case of ldl, binding of apolipoprotein b (apob) to the ldl-r18-20 and proteoglycans17 21 initiates plasma clearance and lipoprotein degradation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HNF4A | up-regulates quantity by expression 
transcriptional regulation
|
LDLR |
0.354 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254454 |
|
|
Homo sapiens |
Enterocyte |
| pmid |
sentence |
| 21123766 |
Recent studies have demonstrated that PCSK9 mRNA expression was upregulated to a greater extent than that of the LDL receptor in human hepatocytes in primary culture. Our findings also support the role of SREBP-2 as a transcriptional regulator of both the LDL receptor and PCSK9 in human enterocytes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYLIP | down-regulates quantity by destabilization 
ubiquitination
|
LDLR |
0.716 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271485 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30896554 |
The RING E3 ubiquitin ligase inducible degrader of the LDL receptor (IDOL, also known as MYLIP) promotes ubiquitylation and subsequent lysosomal degradation of the LDL receptor (LDLR), thus acting to limit uptake of lipoprotein-derived cholesterol into cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SREBF2 | up-regulates quantity by expression
transcriptional regulation
|
LDLR |
0.765 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254453 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21123766 |
Recent studies have demonstrated that PCSK9 mRNA expression was upregulated to a greater extent than that of the LDL receptor in human hepatocytes in primary culture. Our findings also support the role of SREBP-2 as a transcriptional regulator of both the LDL receptor and PCSK9 in human enterocytes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
porfimer | up-regulates activity
chemical activation
|
LDLR |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259302 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1450993 |
Porphyrins are transported in blood mainly by lipoproteins, and the low density lipoprotein (LDL) receptor-mediated pathway is probably one of the important factors involved in the selective accumulation of porphyrins by tumor tissues, as cancer cells generally express much more LDL receptors than normal cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
LDLR
- 
- 