| + |
ANKRD1 | down-regulates quantity by repression 
transcriptional regulation
|
NPPA |
0.333 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253647 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 18273862 |
In vitro calpain-mediated degradation assays, coupled to reporter gene analysis in transfected HeLa cells, strongly suggested that this mutation enhances both the stability of the ANKRD1/CARP protein and its transcriptional repression activity upon the cardiac-specific atrial natriuretic factor (ANF) promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TBX5 | up-regulates quantity by expression 
transcriptional regulation
|
NPPA |
0.575 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255384 |
|
|
Homo sapiens |
Heart |
| pmid |
sentence |
| 18451335 |
TBX5 is expressed, among others, in the embryonic heart and forelimbs.8 In the heart, it regulates transcription of downstream genes such as the atrial natriuretic factor (NPPA) and fibroblast growth factor 10 (FGF10) by the binding to T-box binding elements (TBEs),11 often in combination with the NKX2-5 transcription factor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NPPA | up-regulates 
binding
|
NPR1 |
0.883 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-137600 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15911069 |
Natriuretic peptide receptor-a (npra) is the biological receptor of the peptide hormones atrial natriuretic peptide (anp) and brain natriuretic peptide (bnp) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
JARID2 | down-regulates quantity by repression 
transcriptional regulation
|
NPPA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-224790 |
|
|
Rattus norvegicus |
Cardiomyocyte Cell Line |
| pmid |
sentence |
| 15542826 |
JMJ physically associates with Nkx2.5 and GATA4 in vitro and in vivo as determined by glutathione S-transferase pull-down and immunoprecipitation assays. we show that JMJ represses ANF gene expression by inhibiting transcriptional activities of Nkx2.5 and GATA4. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
CAMTA1 | up-regulates quantity by expression
transcriptional regulation
|
NPPA |
0.442 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261570 |
|
|
Homo sapiens |
LN-229 Cell |
| pmid |
sentence |
| 21857646 |
CAMTA1 itself stimulates the expression of the anti-proliferative peptide NPPA. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
NPPA
- 
- 