| + |
NKX2-5 | up-regulates quantity by expression 
transcriptional regulation
|
ANKRD1 |
0.343 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253646 |
|
|
Rattus norvegicus |
Cardiac Muscle Cell Line |
| pmid |
sentence |
| 9043061 |
Finally, a carp promoter-lacZ transgene, which displays cardiac-specific expression in wild-type and Nkx2-5(+/-) background, was also significantly reduced in Nkx2-5(-/-) embryos, indicating that Nkx2-5 either directly or indirectly regulates carp promoter activity during in vivo cardiogenesis as well as in cultured cardiac myocytes |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
ZNF804A | up-regulates quantity by expression 
transcriptional regulation
|
ANKRD1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269461 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 23434502 |
ZNF804A has been implicated in susceptibility to schizophrenia by several genome-wide association studies (GWAS), follow-up association studies and meta-analyses. ZNF804A was identified as a schizophrenia-associated gene by GWAS and was predicted to play a role in DNA binding and transcription To identify the genes that are affected by ZNF804A, we manipulated the expression of the ZNF804A protein in HEK293 human embryonic kidney cell lines and performed a cDNA microarray analysis followed by qPCR. We found that ZNF804A-overexpression up-regulated four genes (ANKRD1, INHBE, PIK3AP1, and DDIT3) and down-regulated three genes (CLIC2, MGAM, and BIRC3). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DDIT3 | down-regulates quantity by repression 
transcriptional regulation
|
ANKRD1 |
0.277 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254122 |
|
|
Rattus norvegicus |
Cardiomyocyte Cell Line |
| pmid |
sentence |
| 19299913 |
Promoter deletion and reporter analysis revealed that hypoxia transcriptionally activates a GADD153 promoter through the AP-1 element in neonatal cardiomyocytes. Ectopic overexpression of GADD153 resulted in the downregulation of CARP expression. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
ANKRD1 | down-regulates quantity by repression 
transcriptional regulation
|
NPPA |
0.333 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253647 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 18273862 |
In vitro calpain-mediated degradation assays, coupled to reporter gene analysis in transfected HeLa cells, strongly suggested that this mutation enhances both the stability of the ANKRD1/CARP protein and its transcriptional repression activity upon the cardiac-specific atrial natriuretic factor (ANF) promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
ANKRD1
- 
- 