Relation Results

Summary

Name FSHB
Full Name Follitropin subunit beta
Synonyms Follicle-stimulating hormone beta subunit, FSH-B, FSH-beta, Follitropin beta chain |
Primary ID P01225
Links - -
Type protein
Relations 2
Function Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone he ...
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Type: Score: Layout: SPV 
0.3480.371FOXO1FSHBLHX3

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Relations
Regulator
Mechanism
target
score ℹ
+ FOXO1down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation FSHB 0.348
Identifier Residue Sequence Organism Cell Line
SIGNOR-254185 Mus musculus LbetaT2 Cell
pmid sentence
We demonstrate that FOXO1 represses basal and GnRH-induced Fshb transcription in LβT2 cells.
Publications: 1 Organism: Mus Musculus
+ LHX3up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FSHB 0.371
Identifier Residue Sequence Organism Cell Line
SIGNOR-254557 Homo sapiens
pmid sentence
we also demonstrated that LHX3 bound with greater affinity to the wild-type human FSHB promoter compared with the -211 G/T mutation and that LHX3 binding was more effectively competed with excess wild-type oligonucleotide than with the SNP. Finally, we showed that FSHB transcription was decreased in gonadotrope cells with the -211 G/T mutation compared with the wild-type FSHB promoter.
Publications: 1 Organism: Homo Sapiens
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