| + |
POU4F3 | up-regulates quantity by expression 
transcriptional regulation
|
LHX3 |
0.409 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262586 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 17331196 |
Using oligonucleotide microarrays to generate expression profiles of inner ears of Pou4f3(ddl/ddl) mutant and wild-type mice, we have identified and validated Lhx3, a LIM domain transcription factor, as an in vivo target gene regulated by Pou4f3. Lhx3 is a hair cell-specific gene expressed in all hair cells of the auditory and vestibular system as early as embryonic day 16. The level of Lhx3 mRNA is greatly reduced in the inner ears of embryonic Pou4f3 mutant mice. Our data also show that the expression of Lhx3 is regulated differently in auditory and vestibular hair cells. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Inner Ear |
| + |
LHX3 | up-regulates activity
binding
|
ISL1 |
0.606 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-220169 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9452425 |
The Lhx3-Isl1 C terminus interaction was dependent on the LIM domains of Lhx3. The combinatorial expression of the LIM homeodomain proteins Isl1, Isl2, Lhx1, and Lhx3 in subsets of developing motor neurons correlates with the future organization of these neurons into motor columns with distinct innervation targets, implying a functional role for LIM homeodomain protein combinations in the specification of neuronal identity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LHX3 | up-regulates quantity by expression
transcriptional regulation
|
CGA |
0.397 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267207 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10931853 |
Transcription of pituitary alpha-glycoprotein hormone subunit (alpha-GSU) and thyrotropin beta subunit (TSH-beta) genes is stimulated by thyrotropin-releasing hormone (TRH). P-Lim binds to CBP in TRH-dependent manner on this site and that these proteins synergistically activate the human α-GSU promoter during TRH stimulation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Thyroid Gland |
| Pathways: | Thyroid Hormone Metabolism |
| + |
LHX3 | up-regulates activity
binding
|
ISL2 |
0.443 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236836 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 9452425 |
a direct NLI-independent interaction between Lhx3 and the related proteins Isl1 and Isl2 was observed. The combinatorial expression of the LIM homeodomain proteins Isl1, Isl2, Lhx1, and Lhx3 in subsets of developing motor neurons correlates with the future organization of these neurons into motor columns with distinct innervation targets, implying a functional role for LIM homeodomain protein combinations in the specification of neuronal identity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LHX3 | up-regulates quantity by expression 
transcriptional regulation
|
FSHB |
0.378 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254557 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23766128 |
we also demonstrated that LHX3 bound with greater affinity to the wild-type human FSHB promoter compared with the -211 G/T mutation and that LHX3 binding was more effectively competed with excess wild-type oligonucleotide than with the SNP. Finally, we showed that FSHB transcription was decreased in gonadotrope cells with the -211 G/T mutation compared with the wild-type FSHB promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CREBBP | up-regulates activity
binding
|
LHX3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267206 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10931853 |
Transcription of pituitary alpha-glycoprotein hormone subunit (alpha-GSU) and thyrotropin beta subunit (TSH-beta) genes is stimulated by thyrotropin-releasing hormone (TRH). P-Lim and CBP Act Synergistically in TRH Stimulation of the Human α-GSU Promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Thyroid Hormone Metabolism |
3.0
LHX3
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