| + |
EPO | up-regulates quantity by expression 
transcriptional regulation
|
HBB |
0.358 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251783 |
|
|
Mus musculus |
Hematopoietic Cell |
| pmid |
sentence |
| 9168989 |
We describe the roles of Stat5 and of these tyrosine residues in the EPOR in the erythroid differentiation of murine hematopoietic cell line SKT6 which produces hemoglobin in response to EPO. Chimeric receptors carrying the extracellular domain of the EGF receptor and the intracellular domain of the EPOR were introduced into SKT6 cells. Like EPO, EGF equally activated Stat5 and induced hemoglobin. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
EPO | up-regulates 
binding
|
EPOR |
0.873 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-60663 |
|
|
in vitro |
|
| pmid |
sentence |
| 9774108 |
Human erythropoietin is a haematopoietic cytokine required for the differentiation and proliferation of precursor cells into red blood cells. It activates cells by binding and orientating two cell-surface erythropoietin receptors (EPORs) which trigger an intracellular phosphorylation cascade. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-55300 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 9442088 |
Binding of erythropoietin (epo) to the epo receptor (epor) initiates a signaling cascade resulting in tyrosine phosphorylation of several proteins and induction of ap-1 transcription factor(s). |
|
| Publications: |
2 |
Organism: |
In Vitro, Mus Musculus |
| + |
HIF1A | up-regulates quantity
transcriptional regulation
|
EPO |
0.63 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256593 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8756616 |
We demonstrate the involvement of HIF-1 in the activation of VEGF transcription. VEGF 5'-flanking sequences mediated transcriptional activation of reporter gene expression in hypoxic Hep3B cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HIF1A | up-regulates quantity by expression
transcriptional regulation
|
EPO |
0.63 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253695 |
|
|
|
|
| pmid |
sentence |
| 8663540 |
Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric basic helix-loop-helix transcription factor that regulates hypoxia-inducible genes including the human erythropoietin (EPO) gene. |
|
| Publications: |
1 |
| + |
EPO | up-regulates quantity by expression
transcriptional regulation
|
HBA1 |
0.326 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251786 |
|
|
Mus musculus |
Hematopoietic Cell |
| pmid |
sentence |
| 9168989 |
We describe the roles of Stat5 and of these tyrosine residues in the EPOR in the erythroid differentiation of murine hematopoietic cell line SKT6 which produces hemoglobin in response to EPO. Chimeric receptors carrying the extracellular domain of the EGF receptor and the intracellular domain of the EPOR were introduced into SKT6 cells. Like EPO, EGF equally activated Stat5 and induced hemoglobin. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
EPO
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