| + |
CPM | down-regulates activity 
cleavage
|
HBA1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256507 |
Tyr141 |
STVLTSKyR |
in vitro |
|
| pmid |
sentence |
| 8635221 |
Both human plasma carboxypeptidase N (CPN) and membrane-bound carboxypeptidase M (CPM) released the C-terminal arginine (alpha-Arg141) of the alpha chain of human adult hemoglobin. Thus, the hydrolysis of hemoglobin by CPM and CPN demonstrated the contribution of the alpha-Arg141 residue to sustaining the tetrameric structure of hemoglobin and its normal oxygen affinity and vasoactivity. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
CPN1 | down-regulates activity
cleavage
|
HBA1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256508 |
Tyr141 |
STVLTSKyR |
in vitro |
|
| pmid |
sentence |
| 8635221 |
Both human plasma carboxypeptidase N (CPN) and membrane-bound carboxypeptidase M (CPM) released the C-terminal arginine (alpha-Arg141) of the alpha chain of human adult hemoglobin. Thus, the hydrolysis of hemoglobin by CPM and CPN demonstrated the contribution of the alpha-Arg141 residue to sustaining the tetrameric structure of hemoglobin and its normal oxygen affinity and vasoactivity. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
EPAS1 | up-regulates quantity by expression 
transcriptional regulation
|
HBA1 |
0.25 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251792 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20534544 |
We used genomic and candidate gene approaches to search for evidence of such genetic selection. First, a genome-wide allelic differentiation scan (GWADS) comparing indigenous highlanders of the Tibetan Plateau (3,200-3,500 m) with closely related lowland Han revealed a genome-wide significant divergence across eight SNPs located near EPAS1. This gene encodes the transcription factor HIF2alpha, which stimulates production of red blood cells and thus increases the concentration of hemoglobin in blood. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EGF | up-regulates quantity by expression
transcriptional regulation
|
HBA1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251785 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 9168989 |
We describe the roles of Stat5 and of these tyrosine residues in the EPOR in the erythroid differentiation of murine hematopoietic cell line SKT6 which produces hemoglobin in response to EPO. Chimeric receptors carrying the extracellular domain of the EGF receptor and the intracellular domain of the EPOR were introduced into SKT6 cells. Like EPO, EGF equally activated Stat5 and induced hemoglobin. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
HBA1 | up-regulates quantity by expression
transcriptional regulation
|
TNF |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251753 |
|
|
Homo sapiens |
Monocyte |
| pmid |
sentence |
| 11901318 |
Free hemoglobin enhances tumor necrosis factor-alpha production in isolated human monocytes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HBA1 | down-regulates activity 
|
AHSP |
0.771 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251751 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 2545495 |
EDRF is rapidly inactivated by hemoglobin and superoxide. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | up-regulates quantity by expression
transcriptional regulation
|
HBA1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251838 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20162623 |
Our results demonstrate that activin A induced Hb synthesis and promoter activation of the specific erythroid gene, ζ-globin, through p38α and p38β isoforms and their activator, MKK6 (mitogen-activated protein kinase kinase 6). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT5A | up-regulates quantity by expression
transcriptional regulation
|
HBA1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251787 |
|
|
Mus musculus |
Hematopoietic Cell |
| pmid |
sentence |
| 9168989 |
We describe the roles of Stat5 and of these tyrosine residues in the EPOR in the erythroid differentiation of murine hematopoietic cell line SKT6 which produces hemoglobin in response to EPO. Chimeric receptors carrying the extracellular domain of the EGF receptor and the intracellular domain of the EPOR were introduced into SKT6 cells. Like EPO, EGF equally activated Stat5 and induced hemoglobin. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
EIF2AK1 | down-regulates quantity by repression
transcriptional regulation
|
HBA1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251781 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19946423 |
Translation of α- and β-globin is tightly controlled by eIF2 and downregulated by HRI. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EPO | up-regulates quantity by expression
transcriptional regulation
|
HBA1 |
0.326 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251786 |
|
|
Mus musculus |
Hematopoietic Cell |
| pmid |
sentence |
| 9168989 |
We describe the roles of Stat5 and of these tyrosine residues in the EPOR in the erythroid differentiation of murine hematopoietic cell line SKT6 which produces hemoglobin in response to EPO. Chimeric receptors carrying the extracellular domain of the EGF receptor and the intracellular domain of the EPOR were introduced into SKT6 cells. Like EPO, EGF equally activated Stat5 and induced hemoglobin. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
ARSA | up-regulates activity 
acetylation
|
HBA1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251773 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 237937 |
ASA acetylates hemoglobin. Purified acetylated hemoglobin had a slightly increased oxygen affinity and decreased heme-heme interaction. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK11 | up-regulates quantity by expression
transcriptional regulation
|
HBA1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251834 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20162623 |
Our results demonstrate that activin A induced Hb synthesis and promoter activation of the specific erythroid gene, ζ-globin, through p38α and p38β isoforms and their activator, MKK6 (mitogen-activated protein kinase kinase 6). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AHSP | up-regulates quantity by stabilization
binding
|
HBA1 |
0.771 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251770 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18179859 |
α-Hemoglobin stabilizing protein (AHSP) binds α-hemoglobin (Hb), avoiding its precipitation and its pro-oxidant activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HBA1 | down-regulates activity
|
ADAMTS13 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251749 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15367436 |
Incubation of hemoglobin, recombinant and from lysed erythrocytes, with normal plasma revealed an ADAMTS13 inhibitory effect at hemoglobin concentrations of 2 g/L or higher. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HOXB6 | down-regulates quantity by repression
transcriptional regulation
|
HBA1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261637 |
|
|
Homo sapiens |
K-562 Cell |
| pmid |
sentence |
| 15269212 |
HOXB6 protein represses globin transcript levels in stably transfected K562 cells in a DNA-binding dependent fashion. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HBA1 | up-regulates quantity by stabilization
|
APOB |
0.326 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251755 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8611031 |
Hemoglobin induced apolipoprotein B crosslinking in low-density lipoprotein peroxidation. Crosslinked apo B was shown to resist lysosomal degradation, thereby causing accumulation of oxidized LDL in macrophages |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
heme | up-regulates activity
chemical activation
|
HBA1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251909 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26557657 |
Heme is a prosthetic group comprising ferrous iron (Fe2+) and protoporphyrin IX and is an essential cofactor in various biological processes such as oxygen transport (hemoglobin) and storage (myoglobin) and electron transfer (respiratory cytochromes) in addition to its role as a structural component of hemoproteins. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HBA1 | down-regulates activity
|
EDN1 |
0.264 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251767 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8573884 |
Hb inhibitory activity toward ET-1 production might be related to Hb mediated endothelial oxidative injury. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HMOX1 | down-regulates activity
|
HBA1 |
0.256 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251813 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10490932 |
Heme oxygenase (HO), by catabolizing heme to bile pigments, down-regulates cellular hemoprotein, hemoglobin, and heme |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TGFB1 | up-regulates quantity by expression
transcriptional regulation
|
HBA1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251798 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8142649 |
Basic fibroblast growth factor (bFGF) and transforming growth factor-beta 1 (TGF-beta) have both been shown to act on hematopoietic progenitor cells. bFGF antagonized the TGF-beta-mediated induction of hemoglobin in a dose-dependent manner, with 0.1 ng/mL bFGF inhibiting hemoglobin induction by 40% and 10 ng/mL bFGF completely abrogating hemoglobin production. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HBA1 | up-regulates activity
binding
|
CD163 |
0.262 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251747 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16522161 |
These data suggest that hemoglobin may mediate a stimulatory effect on erythropoiesis through the activation of CD163 on hematopoietic progenitor cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HMOX2 | down-regulates activity
|
HBA1 |
0.258 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251814 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10490932 |
Heme oxygenase (HO), by catabolizing heme to bile pigments, down-regulates cellular hemoprotein, hemoglobin, and heme |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ACVR1B | up-regulates quantity by stabilization
|
HBA1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251769 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 2920215 |
Activin, also named FSH-releasing protein, was previously shown to induce hemoglobin accumulation in K562 cells and potentiate the proliferation and differentiation of CFU-E in human bone marrow cultures. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ETV6 | up-regulates quantity by expression
transcriptional regulation
|
HBA1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251794 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15958056 |
Upon erythropoietin exposure, overexpressed TEL stimulated hemoglobin synthesis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HBA1 | up-regulates activity
|
CYP2E1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251765 |
|
|
Homo sapiens |
Hepatocyte |
| pmid |
sentence |
| 19325051 |
Hemoglobin dramatically stimulated CYP 2E1 activity but not the protein expression in quercetin- and ethanol-cotreated hepatocytes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FGF2 | down-regulates quantity by repression
transcriptional regulation
|
HBA1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251796 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8142649 |
Basic fibroblast growth factor (bFGF) and transforming growth factor-beta 1 (TGF-beta) have both been shown to act on hematopoietic progenitor cells. bFGF antagonized the TGF-beta-mediated induction of hemoglobin in a dose-dependent manner, with 0.1 ng/mL bFGF inhibiting hemoglobin induction by 40% and 10 ng/mL bFGF completely abrogating hemoglobin production. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HP | down-regulates quantity
binding
|
HBA1 |
0.734 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251816 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9315856 |
Haptoglobin forms a complex of extremely high affinity with Hb via a well-characterized globin site. Our results show that upon Hb-haptoglobin binding, the globin radical, loses its ability to be terminated by forming globin dimers. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HBA1 | form complex 
binding
|
Hemoglobin |
0.698 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255274 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18179859 |
AHSP does not bind to β-hemoglobin (βHb) or the hemoglobin tetramer, instead, it specifically binds to free αHb, avoiding its precipitation and its pro-oxidant activity. In the presence of βHb, the αHb-AHSP complex is dismembered and βHb displaces AHSP to generate the quaternary structure of hemoglobin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MIF | down-regulates quantity by repression
transcriptional regulation
|
HBA1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251832 |
|
|
Homo sapiens |
K-562 Cell |
| pmid |
sentence |
| 16636133 |
MIF inhibits cytodifferentiation and hemoglobin synthesis of MEL cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
HBA1
- 
- 