| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251843 |
|
|
Mus musculus |
Erythroleukemia Cell |
| pmid |
sentence |
| 16287851 |
NF-E2 is a transcription activator for the regulation of a number of erythroid- and megakaryocytic lineage-specific genes. Here we present evidence that the large subunit of mammalian NF-E2, p45, is sumoylated in vivo in human erythroid K562 cells. we demonstrated by stable transfection assay that only the wild-type p45, but not its mutant form p45 (K368R), could efficiently rescue β-globin gene expression in the p45-null, erythroid cell line CB3. These data together point to a model of mammalian β-like globin gene activation by sumoylated p45/NF-E2 in erythroid cells. |
|
3.0
HBD
- 
- 
transcriptional regulation