Summary

Name CD74
Full Name HLA class II histocompatibility antigen gamma chain
Synonyms HLA-DR antigens-associated invariant chain, Ia antigen-associated invariant chain, Ii, p33 | DHLAG
Primary ID P04233
Links - -
Type protein
Relations 3
Function Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.; FUNCTION

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Relations

Regulator Mechanism target score ℹ
+ MIFup-regulates activity img/direct-activation.png binding CD74 0.725
Publications: 1 Organism: Homo Sapiens
Pathways:Toll like receptors
+ MIFup-regulates img/direct-activation.png binding CD74 0.725
Publications: 1 Organism: Homo Sapiens
Pathways:Toll like receptors
+ CD74up-regulates img/direct-activation.png binding CXCR4 0.547
Publications: 1 Organism: Homo Sapiens
Pathways:Toll like receptors