| + |
PRKCD | down-regulates activity 
phosphorylation
|
CXCR4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260898 |
Ser324 |
LTSVSRGsSLKILSK |
Homo sapiens |
|
| pmid |
sentence |
| 10521508 |
Therefore, internalization of CXCR4 in response to PMA appears to be mediated by activation of protein kinase C | However, mutation of the dileucine motif or the serines at positions 324, 325, 338, and 339 profoundly decreased internalization. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260899 |
Ser325 |
LTSVSRGsSLKILSK |
Homo sapiens |
|
| pmid |
sentence |
| 10521508 |
Therefore, internalization of CXCR4 in response to PMA appears to be mediated by activation of protein kinase C | However, mutation of the dileucine motif or the serines at positions 324, 325, 338, and 339 profoundly decreased internalization. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260900 |
Ser338 |
KGKRGGHsSVSTESE |
Homo sapiens |
|
| pmid |
sentence |
| 10521508 |
Therefore, internalization of CXCR4 in response to PMA appears to be mediated by activation of protein kinase C | However, mutation of the dileucine motif or the serines at positions 324, 325, 338, and 339 profoundly decreased internalization. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260901 |
Ser339 |
GKRGGHSsVSTESES |
Homo sapiens |
|
| pmid |
sentence |
| 10521508 |
Therefore, internalization of CXCR4 in response to PMA appears to be mediated by activation of protein kinase C | However, mutation of the dileucine motif or the serines at positions 324, 325, 338, and 339 profoundly decreased internalization. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| + |
hsa-miR-146a | down-regulates quantity by repression
post transcriptional regulation
|
CXCR4 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277939 |
|
|
Homo sapiens |
U-937 Cell |
| pmid |
sentence |
| 26045293 |
MiR-146a overexpression in U937 cells induces a decrease of CXCR4 protein |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277935 |
|
|
Homo sapiens |
MDA-MB-231 Cell |
| pmid |
sentence |
| 23647548 |
Results indicated that CXCR4 expression was markedly reduced when miR-146a was over-expressed in MDA-MB-231 cells. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277938 |
|
|
Homo sapiens |
HUVEC Cell |
| pmid |
sentence |
| 20023696 |
Expression of CXCR4 was downregulated in clinical samples of KS and this was accompanied by increased expression of miR-146a. Our results demonstrate that K13-induced NF-κB activity suppresses CXCR4 via upregulation of miR-146a. Downregulation of CXCR4 expression by K13 may contribute to KS development by promoting the premature release of KSHV-infected endothelial progenitors into the circulation. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
SNAI2 | up-regulates quantity by expression 
transcriptional regulation
|
CXCR4 |
0.412 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255171 |
|
|
Homo sapiens |
Prostate Cancer Cell Line |
| pmid |
sentence |
| 22074556 |
We demonstrated that forced expression of SLUG elevated CXCR4 and CXCL12 expression in human prostate cancer cell lines PC3, DU145, 22RV1, and LNCaP; conversely, reduced expression of SLUG by shRNA downregulated CXCR4 and CXCL12 expression at RNA and protein levels in prostate cancer cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
hsa-miR-1-5p | down-regulates quantity by repression
post transcriptional regulation
|
CXCR4 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277928 |
|
|
Homo sapiens |
Thyroid Cancer Cell |
| pmid |
sentence |
| 21752897 |
MiR-1 affects CXCR4 protein synthesis by facilitating the specific degradation of CXCR4 mRNA. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
has-mir-126-3p | down-regulates quantity by repression
post transcriptional regulation
|
CXCR4 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277930 |
|
|
Homo sapiens |
HCT-116 Cell |
| pmid |
sentence |
| 27517626 |
Our findings suggested that miR-126 acts as a tumor suppressor by inactivating the RhoA signaling pathway via CXCR4 in colon cancer. And miR-126 may serve as a prognostic marker for monitoring and treating colon cancer. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
hsa-miR-133b | down-regulates quantity by repression
post transcriptional regulation
|
CXCR4 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277931 |
|
|
Homo sapiens |
SW-480 Cell |
| pmid |
sentence |
| 24330809 |
CXCR4 was shown to be a direct target of miR-133b by luciferase reporter assays, and transfection of miR-133b mimics inhibited invasion and stimulated apoptosis of SW-480 and SW-620 CRC cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
hsa-miR-139-5p | down-regulates quantity by repression
post transcriptional regulation
|
CXCR4 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277934 |
|
|
Homo sapiens |
HEp-2 Cell |
| pmid |
sentence |
| 24318902 |
Our results showed that miR-139 expression inhibits proliferation and metastasis of LSCC by repressing the functional expression of CXCR4 and CXCR4 was directly targeted by miR-139. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277932 |
|
|
Homo sapiens |
SGC-7901 Cell |
| pmid |
sentence |
| 21925125 |
MiR-139 acts as a tumor suppressor by directly targeting CXCR4, a key metastasis-promoting receptor, but HER2 and CD44 suppress miR-139 expression through epigenetic mechanisms. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
hsa-miR-150-3p | down-regulates quantity by repression
post transcriptional regulation
|
CXCR4 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277940 |
|
|
Homo sapiens |
CAPAN-2 Cell |
| pmid |
sentence |
| 26622579 |
These results suggested that miRNA-150 may negatively regulate the expression of CXCR4 by directly targeting the 3′UTR of CXCR4 mRNA. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
hsa-mir-494-3p | down-regulates quantity by repression
post transcriptional regulation
|
CXCR4 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277942 |
|
|
Homo sapiens |
PC-3 Cell |
| pmid |
sentence |
| 24644030 |
The constitutive overexpression of miR-494 downregulated the protein level of CXCR4, leading to suppression of proliferation, invasion, and migration of prostate cancer. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277943 |
|
|
Homo sapiens |
MDA-MB-231 Cell |
| pmid |
sentence |
| 25955111 |
MiR-494 suppresses the progression of breast cancer through the Wnt/β-catenin signaling pathway, which is mediated by CXCR4. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
hsa-miR-9-5p | down-regulates quantity by repression
post transcriptional regulation
|
CXCR4 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277951 |
|
|
Homo sapiens |
Nasopharyngeal Carcinoma Cell Line |
| pmid |
sentence |
| 24170200 |
The miR-9-mediated silencing of CXCR4 led to the inactivation of the p38 MAPK pathway. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277950 |
|
|
Homo sapiens |
SCC-9 Cell |
| pmid |
sentence |
| 24141785 |
We demonstrated for the first time that miR-9 functions as a tumor-suppressive miRNA in OSCC via targeting CXCR4 and inhibiting the Wnt/β-catenin signaling pathway |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
ERG | up-regulates quantity by expression
transcriptional regulation
|
CXCR4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253911 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19396168 |
ADAMTS1 and CXCR4, two candidate genes strongly associated with cell migration, were upregulated in the presence of ERG overexpression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YBX1 | up-regulates quantity by expression
transcriptional regulation
|
CXCR4 |
0.272 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255611 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17072343 |
YB-1 knockdown by siRNA upregulated 344 genes, including MDR1, thymidylate synthetase, S100 calcium binding protein and cyclin B, and downregulated 534 genes, including CXCR4, N-myc downstream regulated gene 1, E-cadherin and phospholipase C. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
1-[[4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,8,11-tetrazacyclotetradecane | down-regulates
chemical inhibition
|
CXCR4 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-206268 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| Other |
|
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
miR-146a | up-regulates quantity by expression
post transcriptional regulation
|
CXCR4 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268952 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20516212 |
MiR-221 strongly upregulated GAX.ZEB2 is upregulated by serum and downregulates GAX, while the expression of miR-221 upregulates GAX and downregulates ZEB2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CXCL12 | up-regulates 
binding
|
CXCR4 |
0.802 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-115029 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11859124 |
To study the role of the sdf-1/cxcr4-chemokine/receptor system as a regulator of vertebrate development, we isolated and characterized a cdna encoding sdf-1 of the lower vertebrate xenopus laevis (xsdf-1). Recombinant xsdf-1 was produced in insect cells, purified, and functionally characterized. Although xsdf-1 is only 64-66% identical with its mammalian counterparts, it is indistinguishable from human (h)sdf-1alpha in terms of activating both x. laevis cxcr4 and hcxcr4. Thus, both xsdf-1 and hsdf-1alpha promoted cxcr4-mediated activation of heterotrimeric g(i2) in a cell-free system and induced release of intracellular calcium ions in and chemotaxis of intact lymphoblastic cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MIF | up-regulates activity
binding
|
CXCR4 |
0.379 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252062 |
|
|
Mus musculus |
Monocyte |
| pmid |
sentence |
| 17435771 |
We identify the chemokine receptors CXCR2 and CXCR4 as functional receptors for MIF [] By activating both CXCR2 and CXCR4, MIF displays chemokine-like functions and acts as a major regulator of inflammatory cell recruitment and atherogenesis. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Toll like receptors |
| + |
CD74 | up-regulates
binding
|
CXCR4 |
0.546 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-187461 |
|
|
Homo sapiens |
HEK-293 Cell, Monocyte |
| pmid |
sentence |
| 19665027 |
Cd74 forms functional complexes with cxcr4 that mediate mif-specific signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Toll like receptors |
| + |
CXCR4 | up-regulates
|
Angiogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252266 |
|
|
Homo sapiens |
SUM-102 Cell |
| pmid |
sentence |
| 19584257 |
However, we show that soluble factors secreted by SUM102 breast cancer cells stimulated the expression of MMP-1 and CXCR4 in HMFs. As a result, these stromal cells acquired an invasive and migratory phenotype |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
USP14 | up-regulates quantity by stabilization
deubiquitination
|
CXCR4 |
0.459 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265057 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 26523394 |
The physical interaction of CXCR4 and USP14 is paralleled by USP14-catalyzed deubiquitination of the receptor|We also observed that ubiquitination of CXCR4 facilitated receptor degradation, whereas overexpression of USP14 or RNAi-induced knockdown of USP14 blocked CXCL12-mediated CXCR4 degradation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CXCR4
- 
- 