3.0
Summary
| Name |  CXCR4View Modifications |
| Full Name | C-X-C chemokine receptor type 4 |
| Synonyms | CXC-R4, CXCR-4, FB22, Fusin, HM89, LCR1, Leukocyte-derived seven transmembrane domain receptor, LESTR, Lipopolysaccharide-associated protein 3, LAP-3, LPS-associated protein 3, NPYRL, Stromal cell-derived factor 1 receptor, SDF-1 receptor |
| Primary ID | P61073 |
| Links |  -  -  |
| Type | protein |
| Relations | 14 |
| Inhibitors | 1-[[4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,8,11-tetrazacyclotetradecane |
| Function | Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation (PubMed:10452968, PubMed:28978524, PubMed:18799424, PubMed:24912431). Involved in the AKT signaling cascade (PubMed:24912431). Plays a role in regulation of cell migration, e.g. during wound healing (PubMed:28978524). Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels (PubMed:20228059). Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKCD | down-regulates activity 
phosphorylation
|
CXCR4 | 0.2 |
| Publications: | 4 | Organism: | Homo Sapiens | |
| + | SNAI2 | up-regulates quantity by expression 
transcriptional regulation
|
CXCR4 | 0.414 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ERG | up-regulates quantity by expression
transcriptional regulation
|
CXCR4 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CD74 | up-regulates 
binding
|
CXCR4 | 0.547 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Toll like receptors | |||
| + | USP14 | up-regulates quantity by stabilization
deubiquitination
|
CXCR4 | 0.459 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | 1-[[4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,8,11-tetrazacyclotetradecane | down-regulates
chemical inhibition
|
CXCR4 | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CXCL12 | up-regulates
binding
|
CXCR4 | 0.803 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | YBX1 | up-regulates quantity by expression
transcriptional regulation
|
CXCR4 | 0.272 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CXCR4 | up-regulates
|
Angiogenesis | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | miR-146a | up-regulates quantity by expression
post transcriptional regulation
|
CXCR4 | 0.4 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MIF | up-regulates activity
binding
|
CXCR4 | 0.381 |
| Publications: | 1 | Organism: | Mus Musculus | |
| Pathways: | Toll like receptors | |||