Relation Results

Summary

Name CD3D
Full Name T-cell surface glycoprotein CD3 delta chain
Synonyms T-cell receptor T3 delta chain | T3D
Primary ID P04234
Links - -
Type protein
Relations 4
Function Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cel ...
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Type: Score: Layout: SPV 
0.7250.4870.5510.2CD3DCD3AMFRLCKTRIM13

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Relations
Regulator
Mechanism
target
score ℹ
+ CD3Dform complex img/form-complex.png binding CD3 0.725
Identifier Residue Sequence Organism Cell Line
SIGNOR-255295 Homo sapiens
pmid sentence
The T cell receptor-CD3 complex (TCR-CD3) serves a critical role in the differentiation, survival, and function of T cells, and receptor triggering elicits a complex set of biological responses that serve to protect the organism from infectious agents. The receptor is composed of six different chains that form the TCR heterodimer responsible for ligand recognition, as well as the CD3γε, CD3δε, and ζζ signaling modules.
Publications: 1 Organism: Homo Sapiens
+ AMFRdown-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination CD3D 0.487
Identifier Residue Sequence Organism Cell Line
SIGNOR-272670 Homo sapiens HEK-293 Cell
pmid sentence
Gp78 specifically recruits MmUBC7, a ubiquitin-conjugating enzyme (E2) implicated in ER-associated degradation (ERAD), through a region distinct from the RING finger. gp78 can target itself for proteasomal degradation in a RING finger- and MmUBC7-dependent manner. Importantly, gp78 can also mediate degradation of CD3-delta, a well-characterized ERAD substrate. 
Publications: 1 Organism: Homo Sapiens
+ LCKup-regulates activity img/direct-activation.png phosphorylation CD3D 0.551
Identifier Residue Sequence Organism Cell Line
SIGNOR-259929 Mus musculus T-lymphocyte
pmid sentence
Last, we demonstrate directly that members of the CD3 complex, including the gamma, delta, and epsilon chains, as well as a putative zeta subunit, can be phosphorylated at tyrosine residues by the CD4/CD8.p56lck complex.
Publications: 1 Organism: Mus Musculus
+ TRIM13down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination CD3D 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-271644 Homo sapiens HEK-293 Cell
pmid sentence
RFP2, a gene frequently lost in various malignancies, encodes a protein with RING finger, B-box, and coiled-coil domains that belongs to the RBCC/TRIM family of proteins.Rfp2 Regulates the Stability of the ERAD Substrate CD3-δ. In summary, these experiments demonstrate that Rfp2 functions as a RING-dependent ERAD E3 ubiquitin ligase and regulates the degradation of the ER substrate, CD3-δ.
Publications: 1 Organism: Homo Sapiens
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