3.0
Summary
| Name |  S100B
|
| Full Name | Protein S100-B |
| Synonyms | S-100 protein beta chain, S-100 protein subunit beta, S100 calcium-binding protein B | |
| Primary ID | P04271 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity. |
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transcriptional regulation