| + |
HMGB1 | up-regulates activity 
binding
|
HOXC6 |
0.301 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-219937 |
|
|
in vitro |
|
| pmid |
sentence |
| 8890171 |
We show that HMG1 interacts with proteins encoded by the HOX gene family by establishing protein-protein contacts between the HMG box domains and the HOX homeodomain. The functional role of these interactions was studied using the transcriptional activity of the human HOXD9 protein as a model. HMG1 enhances, in a dose-dependent fashion, the sequence-specific DNA binding activity in vitro, and the transcriptional activation in a co-transfection assay in vivo, of the HOXD9 protein. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
KDM6A | up-regulates quantity by expression
transcriptional regulation
|
HOXC6 |
0.263 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260028 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24561908 |
Evidence for direct involvement of UTX in regulation of HOX gene activity was demonstrated through UTX knockdown experiments in HEK293T cells in which loss of UTX induced transcriptional repression of HOXA and HOXC clusters. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HOXC6 | up-regulates quantity by expression
transcriptional regulation
|
S100B |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261646 |
|
|
Homo sapiens |
GOTO Cell |
| pmid |
sentence |
| 17488478 |
HOXC6 and HOXC11 increase transcription of S100beta gene in BrdU-induced in vitro differentiation of GOTO neuroblastoma cells into Schwannian cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
HOXC6
- 
- 