+ |
NR3C2 | down-regulates quantity by repression
transcriptional regulation
|
ATP1B1 |
0.24 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-254865 |
|
|
Homo sapiens |
CV-1 Cell |
pmid |
sentence |
9694812 |
Together these data indicate that the 21-base pair sequence represents a true MRE/GRE and that optimal activation of the human Na/K-ATPase beta1 promoter is controlled by mineralocorticoid and glucocorticoid hormones. It appears that an interaction of MR with GR on the beta1 promoter effectively down-regulates transcription. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
NR3C1 | down-regulates quantity by repression
transcriptional regulation
|
ATP1B1 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-254864 |
|
|
Homo sapiens |
|
pmid |
sentence |
9694812 |
Together these data indicate that the 21-base pair sequence represents a true MRE/GRE and that optimal activation of the human Na/K-ATPase beta1 promoter is controlled by mineralocorticoid and glucocorticoid hormones. It appears that an interaction of MR with GR on the beta1 promoter effectively down-regulates transcription. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
WFS1 | up-regulates quantity
binding
|
ATP1B1 |
0.408 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-260999 |
|
|
Chlorocebus aethiops |
COS-7 Cell |
pmid |
sentence |
17947299 |
Sodium-potassium ATPase 1 Subunit Is a Molecular Partner of Wolframin, an Endoplasmic Reticulum Protein Involved in ER Stress|We conclude that the interaction may be important for Na+/K+ ATPase beta1 subunit maturation |
|
Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
+ |
RNF183 | down-regulates quantity by destabilization
polyubiquitination
|
ATP1B1 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-272218 |
|
|
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
31732153 |
RNF183 promotes the degradation of Na, K-ATPas. We confirmed that RNF183 interacted with both α1 and β1 subunits; however, we found that RNF183 ubiquitinated only the β1 subunit, not the α1 subunit. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |