Summary

Name NR3C1
Full Name Glucocorticoid receptor
Synonyms GR, Nuclear receptor subfamily 3 group C member 1 | GRL
Primary ID P04150
Links - -
Type protein
Relations 118
Pathways Adipogenesis, Circadian clock, FAP: In vitro induction of adipogenesis, FAP: Adipogenic transcriptional cascade, FAP: Glucocorticoids, FAP: Notch, FAP: GCR-cAMP crosstalk, Glucocorticoid receptor Signaling, Myofiber: Glucocorticoid-induced atrophy, Pericyte: In vitro induction of adipogenesis
Inhibitors mifepristone
Function Receptor for glucocorticoids (GC) (PubMed:27120390). Has a dual mode of action

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation NR3C1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NR3C1 0.497
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis
+ up-regulates activity img/direct-activation.png phosphorylation NR3C1 0.294
Publications: 2 Organism: In Vitro
Pathways:Adipogenesis
+ down-regulates activity img/direct_inhibition.png phosphorylation NR3C1 0.459
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation NR3C1 0.468
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NR3C1 0.49
Publications: 2 Organism: Homo Sapiens, Mus Musculus
Pathways:Glucocorticoid receptor Signaling
+ down-regulates activity img/direct_inhibition.png dephosphorylation NR3C1 0.523
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation NR3C1 0.624
Publications: 1 Organism: Homo Sapiens
Pathways:Glucocorticoid receptor Signaling
+ down-regulates activity img/direct_inhibition.png phosphorylation NR3C1 0.608
Publications: 1 Organism: In Vitro
Pathways:Glucocorticoid receptor Signaling
+ down-regulates img/direct_inhibition.png phosphorylation NR3C1 0.522
Publications: 1 Organism: In Vitro
Pathways:Glucocorticoid receptor Signaling
+ down-regulates img/direct_inhibition.png phosphorylation NR3C1 0.2
Publications: 1 Organism: In Vitro
Pathways:Adipogenesis
+ down-regulates activity img/direct_inhibition.png phosphorylation NR3C1 0.52
Publications: 1 Organism: Homo Sapiens
Pathways:Adipogenesis
+ img/unknown.png phosphorylation NR3C1 0.356
Publications: 1 Organism: In Vitro
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation PPARG 0.401
Publications: 3 Organism: Mus Musculus
Pathways:Adipogenesis, Circadian clock
+ up-regulates activity img/direct-activation.png chemical activation NR3C1 0.8
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png chemical activation NR3C1 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation NCOA1 0.76
Publications: 1 Organism: Homo Sapiens
Pathways:Glucocorticoid receptor Signaling
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation PER1 0.27
Publications: 1 Organism: Homo Sapiens
Pathways:Circadian clock
+ up-regulates quantity img/direct-activation.png transcriptional regulation CEBPD 0.319
Publications: 2 Organism: Mus Musculus
Pathways:Adipogenesis
+ up-regulates quantity img/direct-activation.png DUSP1 0.561
Publications: 1 Organism: Mus Musculus
+ down-regulates activity img/indirect_inhibition.png ERK1/2 0.619
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis
+ up-regulates img/direct-activation.png chemical activation NR3C1 0.8
Publications: 5 Organism: Homo Sapiens
Pathways:Glucocorticoid receptor Signaling
+ down-regulates activity img/indirect_inhibition.png MAPK3 0.522
Publications: 1 Organism: Mus Musculus
Pathways:Glucocorticoid receptor Signaling
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation NR3C1 0.536
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation NR4A2 0.31
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/indirect_inhibition.png Inflammation 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:Glucocorticoid receptor Signaling
+ down-regulates img/direct_inhibition.png phosphorylation NR3C1 0.2
Publications: 1 Organism: In Vitro
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation NR3C1 0.335
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding NR3C1 0.724
Publications: 1 Organism: Homo Sapiens
Pathways:Glucocorticoid receptor Signaling
+ up-regulates quantity img/direct-activation.png transcriptional regulation IRAK3 0.366
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png binding NR3C1 0.53
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CAV1 0.389
Publications: 1 Organism: Homo Sapiens
Pathways:Glucocorticoid receptor Signaling
+ up-regulates quantity img/indirect-activation.png transcriptional regulation SGK1 0.468
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates img/direct-activation.png binding HDAC1 0.456
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates activity img/direct-activation.png chemical activation NR3C1 0.8
Publications: 1 Organism: In Vitro
Pathways:Glucocorticoid receptor Signaling
+ up-regulates activity img/indirect-activation.png Inflammation 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:Glucocorticoid receptor Signaling
+ down-regulates img/direct_inhibition.png binding NR3C1 0.619
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding CEBPB 0.47
Publications: 2 Organism: Rattus Norvegicus, Mus Musculus
Pathways:Adipogenesis
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation NFIL3 0.3
Publications: 1 Organism: Homo Sapiens
Pathways:Circadian clock
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NFKBIA 0.33
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation NR3C1 0.8
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:Glucocorticoid receptor Signaling
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation NR4A3 0.295
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation NFKB1 0.584
Publications: 1 Organism: Homo Sapiens
Pathways:Glucocorticoid receptor Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NR2F2 0.359
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/indirect-activation.png transcriptional regulation PPARG 0.401
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis, Circadian clock
+ up-regulates activity img/direct-activation.png binding NR3C1 0.296
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition NR3C1 0.8
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates img/direct-activation.png chemical activation NR3C1 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Glucocorticoid receptor Signaling
+ up-regulates img/direct-activation.png chemical activation NR3C1 0.8
Publications: 2 Organism: Homo Sapiens
Pathways:Glucocorticoid receptor Signaling
+ down-regulates activity img/indirect_inhibition.png MAPK1 0.608
Publications: 1 Organism: Mus Musculus
Pathways:Glucocorticoid receptor Signaling
+ down-regulates activity img/indirect_inhibition.png Gbeta 0.2
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png chemical activation NR3C1 0.8
Publications: 4 Organism: Homo Sapiens
Pathways:Glucocorticoid receptor Signaling
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation KLF9 0.326
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png chemical activation NR3C1 0.8
Publications: 1 Organism: In Vitro
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation ATP1B1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding NR3C1 0.733
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png NR3C2 0.525
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TSC22D3 0.419
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation TIMELESS 0.254
Publications: 1 Organism: Homo Sapiens
Pathways:Circadian clock
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation HNF4A 0.378
Publications: 1 Organism: Homo Sapiens
Pathways:Glucocorticoid receptor Signaling
+ up-regulates img/direct-activation.png chemical activation NR3C1 0.8
Publications: 3 Organism: Homo Sapiens
Pathways:Glucocorticoid receptor Signaling
+ up-regulates img/direct-activation.png chemical activation NR3C1 0.8
Publications: 4 Organism: Homo Sapiens
Pathways:Glucocorticoid receptor Signaling
+ up-regulates quantity img/direct-activation.png transcriptional regulation G6P 0.2
Publications: 2 Organism: Pongo Pygmaeus, Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation NR3C1 0.418
Publications: 1 Organism: Homo Sapiens
Pathways:Circadian clock
+ form complex img/form-complex.png binding NR3C1/STAT5A 0.542
Publications: 1 Organism: Homo Sapiens
Pathways:Glucocorticoid receptor Signaling
+ up-regulates activity img/direct-activation.png relocalization KAT2B 0.53
Publications: 1
+ up-regulates img/direct-activation.png chemical activation NR3C1 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Glucocorticoid receptor Signaling
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation TDO2 0.342
Publications: 1
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation KLF15 0.381
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CEBPA 0.466
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CEBPA 0.466
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis
+ up-regulates activity img/direct-activation.png binding NR3C1 0.835
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation KLF5 0.296
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation JUN 0.732
Publications: 1 Organism: Homo Sapiens
Pathways:Glucocorticoid receptor Signaling
+ down-regulates activity img/direct_inhibition.png binding AR 0.53
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding STAT5A 0.542
Publications: 1 Organism: Homo Sapiens
Pathways:Glucocorticoid receptor Signaling
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation NR3C1 0.328
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png transcriptional regulation G6PC1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TRIM63 0.334
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation PER2 0.478
Publications: 1 Organism: Homo Sapiens
Pathways:Circadian clock
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation NR4A1 0.328
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation NR3C1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png MAPK14 0.49
Publications: 1 Organism: Mus Musculus
Pathways:Glucocorticoid receptor Signaling
+ up-regulates img/direct-activation.png chemical activation NR3C1 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Glucocorticoid receptor Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CEBPB 0.47
Publications: 1 Organism: Mus Musculus
Pathways:Adipogenesis
+ up-regulates quantity img/indirect-activation.png transcriptional regulation PCK1 0.365
Publications: 2 Organism: Rattus Norvegicus, Homo Sapiens
+ up-regulates activity img/direct-activation.png chemical activation NR3C1 0.8
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation UGT1A1 0.284
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding LCK 0.362
Publications: 1 Organism: Homo Sapiens
Pathways:Glucocorticoid receptor Signaling
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation RXRA 0.442
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png MAPK8 0.624
Publications: 1 Organism: Mus Musculus
Pathways:Glucocorticoid receptor Signaling
+ up-regulates activity img/direct-activation.png binding NR3C1 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Circadian clock
+ down-regulates activity img/direct_inhibition.png NR3C1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png transcriptional regulation FOXO3 0.422
Publications: 1 Organism: Mus Musculus
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NR3C1 0.359
Publications: 1 Organism: Homo Sapiens