Summary

Name CAPN1
Full Name Calpain-1 catalytic subunit
Synonyms Calcium-activated neutral proteinase 1, CANP 1, Calpain mu-type, Calpain-1 large subunit, Cell proliferation-inducing gene 30 protein, Micromolar-calpain, muCANP | CANPL1
Primary ID P07384
Links - -
Type protein
Relations 7
Pathways Alzheimer Disease
Function Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.

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Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png binding CAPN1 0.28
Publications: 1 Organism: Homo Sapiens
Pathways:Alzheimer Disease
+ up-regulates activity img/direct-activation.png chemical activation CAPN1 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png cleavage CDK5/CDK5R1 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:Alzheimer Disease
+ up-regulates activity img/direct-activation.png cleavage GSK3B 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:Alzheimer Disease
+ up-regulates activity img/direct-activation.png cleavage CDK5R1 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:Alzheimer Disease
+ up-regulates activity img/direct-activation.png cleavage GSK3A 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:Alzheimer Disease
+ down-regulates activity img/direct_inhibition.png cleavage MAPT 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:Alzheimer Disease