Relation Results

Summary

Name EPRS1
Full Name Bifunctional glutamate/proline--tRNA ligase
Synonyms Bifunctional aminoacyl-tRNA synthetase, Cell proliferation-inducing gene 32 protein, Glutamatyl-prolyl-tRNA synthetase | GLNS, PARS, QARS, QPRS
Primary ID P07814
Links - -
Type protein
Relations 4
Function Multifunctional protein which is primarily part of the aminoacyl-tRNA synthetase multienzyme complex, also know as multisynthetase complex, that catal ...
View More

Viewer

Type: Score: Layout: SPV 
0.20.20.2CDK5EPRS1Multiaminoacyl-tRNA synthetaseATF4

Search Tools

Refine search:

  • by mechanism


  • by effect
  • by organism:


  • by tissue:


  • by cell-line

▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ CDK5down-regulates img/direct_inhibition.png phosphorylation EPRS1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-171138 Ser886 LSQSSDSsPTRNSEP Homo sapiens Macrophage
pmid sentence
Ser(886) phosphorylation is required for the interaction of nsap1, which blocks eprs binding to target mrnas. The same phosphorylation event induces subsequent binding of ribosomal protein l13a and gapdh and restores mrna binding. Ifn-_ activates cdk5 to phosphorylate ser(886) in the linker domain of glutamyl-prolyl trna synthetase (eprs), the initial event in assembly of the gait complex. Cdk5/p35 also induces, albeit indirectly via a distinct kinase, phosphorylation of ser(999), the second essential event in gait pathway activation
Identifier Residue Sequence Organism Cell Line
SIGNOR-187383 Ser886 LSQSSDSsPTRNSEP Homo sapiens
pmid sentence
Ser(886) phosphorylation is required for the interaction of nsap1, which blocks eprs binding to target mrnas. The same phosphorylation event induces subsequent binding of ribosomal protein l13a and gapdh and restores mrna binding. Ifn-_ activates cdk5 to phosphorylate ser(886) in the linker domain of glutamyl-prolyl trna synthetase (eprs), the initial event in assembly of the gait complex. Cdk5/p35 also induces, albeit indirectly via a distinct kinase, phosphorylation of ser(999), the second essential event in gait pathway activation
Publications: 2 Organism: Homo Sapiens
+ EPRS1form complex img/form-complex.png binding Multiaminoacyl-tRNA synthetase 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270356 Homo sapiens
pmid sentence
In mammalian cells, eight cytoplasmic aminoacyl-tRNA synthetases (AARS), and three non-synthetase proteins, reside in a large multi-tRNA synthetase complex (MSC). the MSC is suggested to be a super-complex of two identical, symmetrically arranged sub-units, each containing a single copy of the constituents, with the exception of LysRS which is present as a dimer in each sub-unit (Figure ​(Figure1B,1B, adapted from (27,28)). The sub-units are proposed to be joined by dimers of AspRS and the ProRS domain of GluProRS, and possibly by LysRS tetramers (20). Four AARSs containing GST-like domains important in protein-protein interactions form a MetRS-AIMP3–GluProRS–AIMP2 core of the complex (27,29). These proteins, together with AspRS, and possibly LeuRS and IleRS (30), form a distinct sub-complex denoted as sub-complex I (27). Sub-complex II consists of AIMP1, GlnRS, ArgRS, a dimer of LysRS, and AIMP2 (which is shared by both sub-complexes).
Publications: 1 Organism: Homo Sapiens
+ ATF4up-regulates quantity by expression img/direct-activation.png transcriptional regulation EPRS1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269419 Homo sapiens
pmid sentence
QRICH1 promotes the expression of translation-related genes. our combined ChIP-seq and RNA-seq analyses identified that QRICH1 and ATF4 were enriched at the promoters of these specific tRNA synthetases, and that ER stress positively regulated their transcription (Fig. 4I). Together, these findings suggest that QRICH1 and ATF4 modulate tRNA metabolic processes to promote secreted protein synthesis during ER stress.
Publications: 1 Organism: Homo Sapiens
a simple tooltip