| + |
INHBA | up-regulates activity 
binding
|
ACVR2B |
0.778 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235142 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8622651 |
Activin binds directly to ActR-IIB, and this complex associates with ActR-IB, which does not bind ligand on its own. In the resulting complex, ActR-IB becomes hyperphosphorylated, and this requires the kinase activity of ActR-IIB. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Multiple sclerosis |
| + |
FST | down-regulates activity 
binding
|
INHBA |
0.84 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251715 |
|
|
Mus musculus |
Skeletal Muscle Satellite Cell |
| pmid |
sentence |
| 24627466 |
Follistatin (FST) is a member of the tissue growth factor β family and is a secreted glycoprotein that antagonizes many members of the family, including activin A, growth differentiation factor 11, and myostatin. |FST315-ΔHBS-Fc induced improvements in muscle repair after injury/atrophy by modulating the early inflammatory phase allowing for increased macrophage density, and Pax7-positive cells leading to an accelerated restoration of myofibers and muscle function. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235134 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22037168 |
Blocking activin action by pre-treatment with its binding protein, follistatin, modifies the inflammatory cytokine cascade, and reduces the severity of the subsequent inflammatory response and mortality |
|
| Publications: |
2 |
Organism: |
Mus Musculus, Homo Sapiens |
| + |
IRX1 | up-regulates quantity by expression 
transcriptional regulation
|
INHBA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261666 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20440264 |
We identified a number of target genes by global microarray analysis after IRX1 transfection combined with real-time PCR and chromatin immunoprecipitation assay.| Upregulation of PTGS2, ANPEP, KDR, UGT8, INHBA, ERMAP, RALGPS1 and SPON1 was confirmed. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
INHBA | up-regulates activity
binding
|
ACVR2A |
0.807 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235138 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1646080 |
A protein of 494 amino acids comprising a ligand-binding extracellular domain, a single membrane-spanning domain, and an intracellular kinase domain with predicted serine/threonine specificity. 125I-activin A binds to transfected COS cells with an affinity of 180 pM and can be competed by activin A, activin B, and inhibin A, but not by transforming growth factor beta 1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Multiple sclerosis |
3.0
INHBA
- 
- 