Name	ITGA2B
Full Name	Integrin alpha-IIb
Synonyms	GPalpha IIb, GPIIb, Platelet membrane glycoprotein IIb \| GP2B, ITGAB
Primary ID	P08514
Links	- -
Type	protein
Relations	4
Function	Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.