Summary

Name RUNX1
Full Name Runt-related transcription factor 1
Synonyms Acute myeloid leukemia 1 protein, Core-binding factor subunit alpha-2, CBF-alpha-2, Oncogene AML-1, Polyomavirus enhancer-binding protein 2 alpha B subunit, PEA2-alpha B, PEBP2-alpha B, SL3-3 enhancer factor 1 alpha B subunit, SL3/AKV core-binding factor alpha B subunit | AML1, CBFA2
Primary ID Q01196
Links - -
Type protein
Relations 80
Pathways Acute Myeloid Leukemia, FLT3 in AML, Onco-fusion proteins in AML, KIT in AML, miRNA in AML, MLL fusion protein in AML, HaematopoiesisTranscriptionalControl, NPM1_new
Function Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters (Probable). Essential for the development of normal hematopoiesis (PubMed:17431401). Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter (PubMed:10207087, PubMed:14970218). Inhibits KAT6B-dependent transcriptional activation (By similarity). Involved in lineage commitment of immature T cell precursors. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation. CBF complexes binding to the transcriptional silencer is essential for recruitment of nuclear protein complexes that catalyze epigenetic modifications to establish epigenetic ZBTB7B silencing (By similarity). Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (PubMed:17377532). Positively regulates the expression of RORC in T-helper 17 cells (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png methylation RUNX1 0.288
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RUNX1 0.593
Publications: 5 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, Onco-fusion proteins in AML
+ up-regulates activity img/direct-activation.png phosphorylation RUNX1 0.557
Publications: 3 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RUNX1 0.347
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RUNX1 0.347
Publications: 5 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, KIT in AML
+ up-regulates activity img/direct-activation.png phosphorylation RUNX1 0.2
Publications: 4 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RUNX1 0.2
Publications: 4 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation RUNX1 0.2
Publications: 4 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation RUNX1 0.2
Publications: 3 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3 in AML, KIT in AML, NPM1_new
+ down-regulates activity img/direct_inhibition.png phosphorylation RUNX1 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation RUNX1 0.593
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, Onco-fusion proteins in AML
+ up-regulates activity img/direct-activation.png phosphorylation RUNX1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3 in AML, KIT in AML, NPM1_new
+ down-regulates activity img/direct_inhibition.png phosphorylation RUNX1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation RUNX1 0.347
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, KIT in AML
+ up-regulates activity img/direct-activation.png phosphorylation RUNX1 0.347
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, KIT in AML
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation MYC 0.345
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3 in AML, KIT in AML, miRNA in AML, MLL fusion protein in AML, NPM1_new
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ELANE 0.328
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation hsa-mir-223 0.4
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, miRNA in AML
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation RUNX1 0.29
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, MLL fusion protein in AML, NPM1_new
+ up-regulates quantity by stabilization img/direct-activation.png binding RUNX1 0.838
Publications: 2 Organism: Mus Musculus
Pathways:HaematopoiesisTranscriptionalControl
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation RUNX1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation RUNX1 0.2
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, miRNA in AML, MLL fusion protein in AML
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation CCL3 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation RUNX1 0.2
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, miRNA in AML, MLL fusion protein in AML
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BAALC 0.34
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation miR-155 0.4
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, miRNA in AML
+ form complex img/form-complex.png binding ELF4/RUNX1 0.357
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MECOM 0.507
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, Onco-fusion proteins in AML, MLL fusion protein in AML
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation GP1BA 0.371
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding RUNX1 0.419
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding RUNX1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding IKK-complex 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png transcriptional regulation HHEX 0.277
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3 in AML
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CDKN2A 0.269
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, Onco-fusion proteins in AML, NPM1_new
+ down-regulates activity img/direct_inhibition.png binding RUNX1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, Onco-fusion proteins in AML, KIT in AML
+ down-regulates activity img/direct_inhibition.png binding RUNX1 0.507
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, Onco-fusion proteins in AML, MLL fusion protein in AML
+ up-regulates quantity by stabilization img/direct-activation.png binding RUNX1 0.544
Publications: 2 Organism: Homo Sapiens
Pathways:HaematopoiesisTranscriptionalControl
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation SPI1 0.674
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, miRNA in AML, MLL fusion protein in AML, HaematopoiesisTranscriptionalControl
+ up-regulates activity img/direct-activation.png binding RUNX1 0.427
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation RUNX1 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, Onco-fusion proteins in AML, MLL fusion protein in AML
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation KIT 0.345
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, Onco-fusion proteins in AML, KIT in AML
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation RUNX1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png relocalization RUNX1 0.29
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, MLL fusion protein in AML, NPM1_new
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation RUNX1 0.2
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, miRNA in AML, MLL fusion protein in AML
+ up-regulates activity img/direct-activation.png binding RUNX1 0.627
Publications: 1 Organism: Homo Sapiens
Pathways:HaematopoiesisTranscriptionalControl
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation BCR-ABL 0.2
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, Onco-fusion proteins in AML
+ up-regulates img/direct-activation.png binding RUNX1 0.48
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ITGA2B 0.469
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding Core Binding Factor complex 0.838
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png RUNX1 0.374
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3 in AML, miRNA in AML, NPM1_new
+ up-regulates img/indirect-activation.png Differentiation 0.7
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3 in AML, Onco-fusion proteins in AML, KIT in AML, miRNA in AML, MLL fusion protein in AML, HaematopoiesisTranscriptionalControl, NPM1_new
+ down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation ANKRD26 0.2
Publications: 1 Organism: Homo Sapiens