4.0
Summary
| Name |  ITGA5
|
| Full Name | Integrin alpha-5 |
| Synonyms | CD49 antigen-like family member E, Fibronectin receptor subunit alpha, Integrin alpha-F, VLA-5 | FNRA |
| Primary ID | P08648 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430). ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (PubMed:31331973). |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | ITGA5 | form complex 
binding
|
A5/b1 integrin | 0.915 |
| Publications: | 1 | |||
| + | HOXD3 | up-regulates quantity by expression 
transcriptional regulation
|
ITGA5 | 0.251 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | DIDO1 | up-regulates quantity by expression
transcriptional regulation
|
ITGA5 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |