Relation Results

Summary

Name IGFBP1
Full Name Insulin-like growth factor-binding protein 1
Synonyms IBP-1, IGF-binding protein 1, IGFBP-1, Placental protein 12, PP12 | IBP1
Primary ID P08833
Links - -
Type protein
Relations 4
Function IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on ...
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Type: Score: Layout: SPV 
0.3840.4170.20.2FOXO1IGFBP1HOXA10HOXB4FOXO

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Relations
Regulator
Mechanism
target
score ℹ
+ FOXO1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IGFBP1 0.384
Identifier Residue Sequence Organism Cell Line
SIGNOR-68152 Homo sapiens
pmid sentence
Reporter gene studies in hepg2 hepatoma cells show that fkhr stimulates insulin-like growth factor-binding protein-1 promoter activity through an irs
Publications: 1 Organism: Homo Sapiens
+ HOXA10down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation IGFBP1 0.417
Identifier Residue Sequence Organism Cell Line
SIGNOR-254467 Homo sapiens Endometrial Stromal Cell
pmid sentence
The functional role of HOXA10 in IGFBP1 expression was further explored using human endometrial stromal cells (HSC). Overexpression of HOXA10 in HSC resulted in a decrease of IGFBP1 mRNA, whereas silencing HOXA10 caused an increase of IGFBP1 mRNA, even in the presence of H + dbcAMP. These data demonstrate that HOXA10 negatively influences IGFBP1 expression in decidualizing cells.
Publications: 1 Organism: Homo Sapiens
+ HOXB4up-regulates quantity by expression img/direct-activation.png transcriptional regulation IGFBP1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-261636 Homo sapiens
pmid sentence
These data showed that Hox genes selectively activate the transcription of theIGFBP-1
Publications: 1 Organism: Homo Sapiens
+ FOXOup-regulates quantity by expression img/indirect-activation.png transcriptional regulation IGFBP1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252925 Homo sapiens
pmid sentence
Reporter gene studies in hepg2 hepatoma cells show that fkhr stimulates insulin-like growth factor-binding protein-1 promoter activity through an irs
Publications: 1 Organism: Homo Sapiens
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